Evidence map›Paper›PMID 39978811›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

Hanan Babeker, Fabrice Ngoh Njotu, Jessica Pougoue Ketchemen, Alissar Monzer, Anjong Florence Tikum, Alireza Doroudi, Emmanuel Nwangele, Maruti Uppalapati, Humphrey Fonge

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Nectin-4-Targeted Radiotheranostics for Personalized Cancer Therapy: A Systematic Review.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Pooled it
  2. Prognostic value and diagnostic performance of nectin-4-targeted [European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Preliminary biological evaluation of a [EJNMMI radiopharmacy and chemistry · 2026
    Article
  7. Article
  8. Journal of nanobiotechnology · 2026
    Article
  9. Review
  10. The molecular blueprint of targeted radionuclide therapy.Nature reviews. Clinical oncology · 2025
    Review
  11. Review
  12. Scalability study on [EJNMMI radiopharmacy and chemistry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hanan BabekerDepartment of Medical Imaging, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Fabrice Ngoh NjotuDepartment of Medical Imaging, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Jessica Pougoue KetchemenDepartment of Medical Imaging, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Alissar MonzerDepartment of Medical Imaging, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Anjong Florence TikumDepartment of Medical Imaging, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Alireza DoroudiDepartment of Medical Imaging, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Emmanuel NwangeleDepartment of Medical Imaging, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Maruti UppalapatiDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; humphrey.fonge@crchudequebec.ulaval.ca maruti.uppalapati@usask.ca.
Humphrey FongeDepartment of Medical Imaging, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; humphrey.fonge@crchudequebec.ulaval.ca maruti.uppalapati@usask.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nectin-4 is an overexpressed biomarker in 60%-70% of triple-negative breast cancer (TNBC) cases and an ideal target for radiotherapy and PET imaging. In this study, theranostic radioimmunoconjugates were developed using a fully human anti-nectin-4 antibody (N4MU01). The imaging properties and therapeutic effectiveness of the radioimmunoconjugates were evaluated using TNBC models.

Indexed as

ActiniumCell Adhesion MoleculesImmunoconjugatesRadioisotopesTheranostic NanomedicineTriple Negative Breast NeoplasmsZirconiumAnimalsCell Line, TumorFemaleHumansIsotope LabelingMiceMice, Inbred BALB CNectinsPositron-Emission TomographyActiniumActinium-225Cell Adhesion MoleculesImmunoconjugatesNECTIN4 protein, humanNectinsRadioisotopesZirconiumZirconium-89human anti–nectin-4 antibodynectin-4PET/CTradioimmunoconjugatestargeted α-particle therapytriple-negative breast cancer

Identifiers

PMID39978811
PMCPMC11960605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.