ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2025
Multivariate Links Between the Developmental Timing of Adversity Exposure and White Matter Tract Connectivity in Adulthood.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Unpredictability is a childhood adversity that contributes to mental health problems.Nature. Mental health · 2026Article
- Corticolimbic structure-function coupling is sensitive to childhood adversity and buffers adversity-related symptoms during development.bioRxiv : the preprint server for biology · 2025Article
- Leveraging multivariate approaches to advance the science of early-life adversity.Child abuse & neglect · 2025Review
- Childhood Adversity Is Associated With Longitudinal White Matter Changes After Adulthood Trauma.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Early life adversity increases risk for chronic post-traumatic pain, data from humans and rodents.Pain · 2025Article
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Abstract
backgroundEarly-life adversity is pervasive worldwide and represents a potent risk factor for increased mental health burden across the lifespan. However, there is substantial individual heterogeneity in associations between adversity exposure, neurobiological changes, and mental health problems. Accounting for key features of adversity such as the developmental timing of exposure may clarify associations between adversity, neurodevelopment, and mental health.
methodsIn the current study, we leveraged sparse canonical correlation analysis to characterize modes of covariation between adversity exposure across development and the connectivity of white matter tracts throughout the brain in a sample of 107 adults.
resultsWe found that adversity exposure during preschool age and middle childhood (ages 4-5 and 8 years in particular) were consistently linked across diffusion metrics with alterations in white matter tract connectivity. Whereas tracts supporting sensorimotor functions showed higher connectivity with higher preschool-age and middle childhood adversity exposure, tracts supporting cortico-cortical communication showed lower connectivity. Furthermore, latent patterns of tract connectivity associated with adversity experienced across preschool age and middle childhood (ages 3-8) were associated with posttraumatic stress symptoms in adulthood.
conclusionsOur findings underscore that adversity exposure may differentially affect white matter in a function- and developmental timing-specific manner and suggest that adversity experienced from ages 3 to 8 years may shape the development of white matter tracts across the brain in ways that are relevant for mental health in adulthood.
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