ReviewThe lancet. Diabetes & endocrinology2025
Realigning diabetes regimens in older adults: a 4S Pathway to guide simplification and deprescribing strategies.
Review in The lancet. Diabetes & endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Metabolic and vascular outcomes after transition to the MiniMed 780G system in adults ≥65 years with type 1 diabetes: a randomised, single-centre study.Diabetologia · 2026Trial
- Pharmacist Intervention for Safer Prescribing in Patients With Type 2 Diabetes at High Risk: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Diabetes medication use in the last year of life in people living with dementia in the United Kingdom and Australia.European geriatric medicine · 2026Article
- Review
- Adherence and Persistence Among Individuals Living With Type 2 Diabetes and Using a Free Combination of Basal Insulin and an Injectable Glucagon-Like Peptide-1 Receptor Agonist Versus a Fixed-Ratio Combination Therapy: A Japanese Database Study.Diabetes, obesity & metabolism · 2026Observational
- Article
- Optimizing type 2 diabetes management in older adults with cancer through comprehensive geriatric assessment-guided medication reviews: a monocentric retrospective study.BMC geriatrics · 2026Observational
- Challenges and Opportunities for Improving Care for Type 1 Diabetes in Older Adulthood.Diabetes care · 2026Review
- Intermittently scanned CGM in older adults with type 2 diabetes not taking insulin: iMMEDIATE post hoc analysis.Journal of the Endocrine Society · 2026Article
- Preparing to Meet the Needs of a Growing Older Adult Population with Type 1 Diabetes: A Narrative Review.Journal of general internal medicine · 2026Review
- The practice of family pharmacists in managing polypharmacy for home-based elderly patients.Journal of family medicine and primary care · 2026Article
- Frailty-Informed Deprescribing of Glucose-Lowering Therapy in Older Adults with Type 2 Diabetes: A Pragmatic Clinical Framework.Clinical interventions in aging · 2026Article
- 13. Older Adults: Standards of Care in Diabetes-2026.Diabetes care · 2026Review
- Validation of a novel patient-reported measure of the burden of digital care in diabetes.BMC medicine · 2025Article
- Comment on: Editor's Note on Clin-STAR Corner: Practice-Changing Advances in Diabetes Care.Journal of the American Geriatrics Society · 2025Article
- Life stage transitions for people with type 1 diabetes.The lancet. Diabetes & endocrinology · 2025Review
- Association between hypoglycaemic drug de-intensification, mortality and hospital admission in older adults with type 2 diabetes: a cohort study emulating a target trial.Age and ageing · 2025Article
- Development of the TBQ+D: A Novel Patient-Reported Measure of The Burden of Digital Care.Patient preference and adherence · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
18 authors.
Funding
Abstract
Treating older people with diabetes is challenging due to multiple medical comorbidities that might interfere with patients' ability to perform self-care. Most diabetes guidelines focus on improving glycaemia through addition of medications, but few address strategies to reduce medication burden for older adults-a concept known as deprescribing. Strategies for deprescribing might include stopping high-risk medications, decreasing the dose, or substituting for less harmful agents. Accordingly, glycaemic management strategies for older adults with type 1 and type 2 diabetes not responding to their current regimen require an understanding of how and when to realign therapy to meet patient's current needs, which represents a major clinical practice gap. With the gap in guidance on how to deprescribe or otherwise adjust therapy in older adults with diabetes in mind, the International Geriatric Diabetes Society, an organisation dedicated to improving care of older individuals with diabetes, convened a Deprescribing Consensus Initiative in May, 2023, to discuss Optimization of diabetes treatment regimens in older adults: the role of de-prescribing, de-intensification and simplification of regimens. The recommendations from this group initiative are discussed and described in this Review.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.