Evidence map›Paper›PMID 39978053›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2025

Alpha rhythm and Alzheimer's disease: Has Hans Berger's dream come true?

Claudio Babiloni, Xianghong Arakaki, Sandra Baez, Robert J Barry, Alberto Benussi, Katarzyna Blinowska, Laura Bonanni, Barbara Borroni, Jorge Bosch Bayard, Giuseppe Bruno and 79 more

Abstract readHistorical Article
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Tracking electrophysiological signatures of Alzheimer's disease: a systematic review of multimodal studies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Pooled it
  2. Diagnostic utility of electrophysiological markers for early and differential diagnosis of Alzheimer's, Frontotemporal, and Lewy Body dementias: A systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

89 authors.

Claudio BabiloniDepartment of Physiology and Pharmacology "Vittorio Erspamer," Sapienza University of Rome, Rome, Italy; San Raffaele of Cassino, Cassino, (FR), Italy. Electronic address: claudio.babiloni@uniroma1.it.
Xianghong ArakakiCognition and Brain Integration Laboratory, Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, USA.
Sandra BaezUniversidad de los Andes, Bogota, Colombia; Global Brain Health Institute (GBHI), University of California, San Francisco, USA; Trinity College Dublin, Dublin, Ireland.
Robert J BarryBrain & Behaviour Research Institute and School of Psychology, University of Wollongong, Wollongong 2522, Australia.
Alberto BenussiNeurology Unit, Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Katarzyna BlinowskaDepartment of Biomedical Physics, Faculty of Physics, University of Warsaw, Poland; Nalecz Institute of Biocybernetics and Biomedical Engineering, Warsaw, Poland.
Laura BonanniDepartment of Medicine, Aging Sciences University G. d'Annunzio of Chieti-Pescara Chieti 66100 Chieti, Italy.
Barbara BorroniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia 25125, Italy.
Jorge Bosch BayardFacultad de Psicología, Universidad Autonoma de Madrid, Madrid, Spain.
Giuseppe BrunoDepartment of Human Neuroscience, Sapienza University of Rome, Rome, Italy.
Alessia CacciottiBrain Connectivity Laboratory, Department of Neuroscience and Neurorehabilitation, IRCCS San Raffaele Roma, Rome, Italy; Department of Theoretical and Applied Sciences, eCampus University, Novedrate, Como, Italy.
Filippo CarducciDepartment of Physiology and Pharmacology "Vittorio Erspamer," Sapienza University of Rome, Rome, Italy.
John CarinoClinical Neurophysiology, Royal Melbourne Hospital, Parkville, Melbourne, Australia.
Matteo CarpiDepartment of Physiology and Pharmacology "Vittorio Erspamer," Sapienza University of Rome, Rome, Italy.
Antonella ConteDepartment of Human Neuroscience, Sapienza University of Rome, Rome, Italy; IRCCS Neuromed, Pozzilli, Italy.
Josephine CruzatLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago, Chile.
Fabrizia D'AntonioDepartment of Human Neuroscience, Sapienza University of Rome, Rome, Italy.
Stefania Della PennaDepartment of Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University of Chieti and Pescara, Chieti, Italy; Institute for Advanced Biomedical Technologies (ITAB), "G. d'Annunzio" University of Chieti and Pescara, Chieti, Italy.
Claudio Del PercioDepartment of Physiology and Pharmacology "Vittorio Erspamer," Sapienza University of Rome, Rome, Italy.
Pierfilippo De SanctisAlbert Einstein College of Medicine, Department of Neurology, Bronx, NY 10461, USA.
Javier EscuderoInstitute for Imaging, Data and Communications, School of Engineering, University of Edinburgh, UK.
Giovanni FabbriniDepartment of Human Neuroscience, Sapienza University of Rome, Rome, Italy; IRCCS Neuromed, Pozzilli, Italy.
Francesca R FarinaThe University of Chicago Division of the Biological Sciences 5841 S Maryland Avenue Chicago, IL 60637, USA; Global Brain Health Institute (GBHI), Trinity College Dublin, Ireland.
Francisco J FragaEngineering, Modeling and Applied Social Sciences Center, Federal University of ABC, Santo André, Brazil.
Peter FuhrDepartment of Neurology, Hospitals of the University of Basel, Basel, Switzerland.
Ute GschwandtnerDepartment of Neurology, Hospitals of the University of Basel, Basel, Switzerland.
Bahar GüntekinDepartment of Biophysics, School of Medicine, Istanbul Medipol University, Istanbul, Turkey; Research Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Istanbul, Turkey.
Yi GuoDepartment of Neurology, Shenzhen People's Hospital and The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, China; Shenzhen Bay Laboratory, Shenzhen, China; Tianjin Huanhu Hospital, Tianjin, China.
Mihaly HajosCognito Therapeutics, Cambridge, MA, USA; Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
Mark HallettHuman Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 7D37, 10 Center Drive, Bethesda, MD 20892-1428, USA.
Harald HampelSorbonne University, Alzheimer Precision Medicine, AP-HP, Pitié-Salpêtrière Hospital, Boulevard de l'hôpital, F-75013 Paris, France.
Lutfu HanoğluResearch Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Istanbul, Turkey; Department of Neurology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
Ira HaraldsenDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
Mahmoud HassanMINDIG, F-35000 Rennes, France; School of Science and Engineering, Reykjavik University, Reykjavik, Iceland.
Christoffer Hatlestad-HallDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
András Attila HorváthNeurocognitive Research Centre, Nyírő Gyula National Institute of Psychiatry and Addictology, Budapest, Hungary; Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary; Research Centre for Natural Sciences, HUN-REN, Budapest, Hungary.
Agustin IbanezLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago, Chile; Global Brain Health Institute (GBHI), Trinity College Dublin, Ireland; Cognitive Neuroscience Center, Universidad de San Andrés, Victoria, Buenos Aires, Argentina.
Francesco InfarinatoRehabilitation Bioengineering Laboratory, IRCCS San Raffaele Roma, Rome, Italy.
Alberto Jaramillo-JimenezCentre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway; Grupo de Neurociencias de Antioquia (GNA), Universidad de Antioquia, Medellín, Colombia.
Jaeseung JeongDepartment of Brain and Cognitive Sciences, Korea Advanced Institute of Science & Technology (KAIST), Daejeon 34141, South Korea.
Yang JiangAging Brain and Cognition Laboratory, Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY, USA; Sanders Brown Center on Aging, College of Medicine, University of Kentucky, Lexington, KY, USA.
Maciej KamińskiDepartment of Biomedical Physics, Faculty of Physics, University of Warsaw, Poland.
Giacomo KochHuman Physiology Unit, Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy; Experimental Neuropsychophysiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.
Sanjeev KumarDepartment of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Giorgio LeodoriDepartment of Human Neuroscience, Sapienza University of Rome, Rome, Italy; IRCCS Neuromed, Pozzilli, Italy.
Gang LiReal World Evidence & Medical Value, Global Medical Affairs, Neurology, Eisai Inc., New Jersey, USA.
Roberta LizioDepartment of Physiology and Pharmacology "Vittorio Erspamer," Sapienza University of Rome, Rome, Italy; Oasi Research Institute - IRCCS, Troina, Italy.
Susanna LopezDepartment of Physiology and Pharmacology "Vittorio Erspamer," Sapienza University of Rome, Rome, Italy.
Raffaele FerriOasi Research Institute - IRCCS, Troina, Italy.
Fernando MaestúCenter For Cognitive and Computational Neuroscience, Complutense University of Madrid, Spain.
Camillo MarraDepartment of Psychology, Catholic University of Sacred Heart, Milan, Italy; Memory Clinic, Foundation Policlinico Agostino Gemelli IRCCS, Rome, Italy.
Laura MarzettiInstitute for Advanced Biomedical Technologies (ITAB), "G. d'Annunzio" University of Chieti and Pescara, Chieti, Italy; Department of Engineering and Geology, "G. d'Annunzio" University of Chieti and Pescara, Pescara, Italy.
William McGeownDepartment of Psychological Sciences & Health, University of Strathclyde, Graham Hills Building, 40 George Street, Glasgow, UK.
Francesca MiragliaBrain Connectivity Laboratory, Department of Neuroscience and Neurorehabilitation, IRCCS San Raffaele Roma, Rome, Italy; Department of Theoretical and Applied Sciences, eCampus University, Novedrate, Como, Italy.
Sebastian MoguilnerLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago, Chile; Cognitive Neuroscience Center, Universidad de San Andrés, Victoria, Buenos Aires, Argentina; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Davide V MorettiAlzheimer's Rehabilitation Operative Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Faisal MushtaqSchool of Psychology, University of Leeds, Leeds, UK; NIHR Leeds Biomedical Research Centre, Leeds, UK.
Giuseppe NoceIRCCS Synlab SDN, Naples, Italy.
Lorenzo NucciBrain Connectivity Laboratory, Department of Neuroscience and Neurorehabilitation, IRCCS San Raffaele Roma, Rome, Italy.
John OchoaNeurophysiology Laboratory GNA-GRUNECO. Universidad de Antioquia, Antioquia, Colombia.
Paolo OnoratiDepartment of Physiology and Pharmacology "Vittorio Erspamer," Sapienza University of Rome, Rome, Italy.
Alessandro PadovaniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; Department of Continuity of Care and Frailty, Neurology Unit, ASST Spedali Civili Hospital, Brescia, Italy; Neurobiorepository and Laboratory of Advanced Biological Markers, University of Brescia, ASST Spedali Civili Hospital, Brescia, Italy; Laboratory of Digital Neurology and Biosensors, University of Brescia, Brescia, Italy; Brain Health Center, University of Brescia, Brescia, Italy.
Chiara PappaletteraBrain Connectivity Laboratory, Department of Neuroscience and Neurorehabilitation, IRCCS San Raffaele Roma, Rome, Italy; Department of Theoretical and Applied Sciences, eCampus University, Novedrate, Como, Italy.
Mario Alfredo ParraDepartment of Psychological Sciences & Health, University of Strathclyde, Graham Hills Building, 40 George Street, Glasgow, UK.
Matteo PardiniDepartment of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, (DINOGMI), University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Roberto Pascual-MarquiThe KEY Institute for Brain-Mind Research, University Hospital of Psychiatry, Zurich, Switzerland.
Walter PaulusDepartment of Neurology, Ludwig-Maximilians University Munich, Munich, Germany; University Medical Center Göttingen, Göttingen, Germany.
Vittorio PizzellaDepartment of Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University of Chieti and Pescara, Chieti, Italy; Institute for Advanced Biomedical Technologies (ITAB), "G. d'Annunzio" University of Chieti and Pescara, Chieti, Italy.
Pavel PradoEscuela de Fonoaudiología, Facultad de Odontología y Ciencias de la Rehabilitación, Universidad San Sebastián, Santiago, Chile.
Géraldine RauchsNormandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NeuroPresage Team, GIP Cyceron, 14000 Caen, France.
Petra RitterBerlin Institute of Health, Charité, Universitätsmedizin Berlin, Berlin, Germany; Department of Neurology with Experimental Neurology, Charité, Universitätsmedizin Berlin, Berlin, Germany; Bernstein Focus State Dependencies of Learning and Bernstein Center for Computational Neuroscience, Berlin, Germany; Einstein Center for Neuroscience Berlin, Berlin, Germany; Einstein Center Digital Future, Berlin, Germany.
Marco SalvatoreIRCCS Synlab SDN, Naples, Italy.
Hernando Santamaria-GarcíaPontificia Universidad Javeriana (PhD Program in Neuroscience), Bogotá, Colombia; Center of Memory and Cognition Intellectus, Hospital Universitario San Ignacio Bogotá, San Ignacio, Colombia.
Michael SchirnerBerlin Institute of Health, Charité, Universitätsmedizin Berlin, Berlin, Germany; Department of Neurology with Experimental Neurology, Charité, Universitätsmedizin Berlin, Berlin, Germany; Bernstein Focus State Dependencies of Learning and Bernstein Center for Computational Neuroscience, Berlin, Germany; Einstein Center for Neuroscience Berlin, Berlin, Germany; Einstein Center Digital Future, Berlin, Germany.
Andrea SoricelliIRCCS Synlab SDN, Naples, Italy; Department of Medical, Movement and Wellbeing Sciences, University of Naples Parthenope, Naples, Italy.
John-Paul TaylorTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Hatice TankisiDepartment of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.
Franca TecchioConsiglio Nazionale delle Ricerche (CNR), Istituto di Scienze e Tecnologie della Cognizione (ISTC), Roma, Italy.
Stefan TeipelGerman Center for Neurodegenerative Diseases (DZNE) Rostock, Rostock, Germany.
Alpha Tom KodamullilDepartment of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Sankt Augustin, Germany.
Antonio Ivano TriggianiNeurophysiology of Epilepsy Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Mitchell Valdes-SosaCuban Center for Neuroscience, Havana, Cuba.
Pedro Valdes-SosaCuban Center for Neuroscience, Havana, Cuba; The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, China.
Fabrizio VecchioUniversidad de los Andes, Bogota, Colombia; Brain Connectivity Laboratory, Department of Neuroscience and Neurorehabilitation, IRCCS San Raffaele Roma, Rome, Italy.
Keith VosselDepartment of Neurology, David Geffen School of Medicine at University of California, Los Angeles, CA, USA.
Dezhong YaoThe Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, China.
Görsev YenerDepartment of Neurology, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey; Izmir Biomedicine and Genome Center, Izmir, Turkey.
Ulf ZiemannDepartment of Neurology & Stroke, University of Tübingen, Tübingen, Germany; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Anita KamondiNeurocognitive Research Centre, Nyírő Gyula National Institute of Psychiatry and Addictology, Budapest, Hungary; Department of Neurosurgery and Neurointervention and Department of Neurology, Semmelweis University, Budapest, Hungary.

Funding

Strategies for Targeting Astrocyte Reactivity in Alzheimer's Disease and Related DementiasP01AG078116 · NIA · UNIVERSITY OF KENTUCKY · PI PETER T. NELSON · 2022 to 2026
$25.0M
University of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI LINDA J VAN ELDIK · 2021 to 2026
$23.5M
NIA NIH HHS P01 AG078116NIA NIH HHS P30 AG072946RRD VA I21 RX003173
6 · The paper itself

Abstract

In this "centenary" paper, an expert panel revisited Hans Berger's groundbreaking discovery of human restingstate electroencephalographic (rsEEG) alpha rhythms (8-12 Hz) in 1924, his foresight of substantial clinical applications in patients with "senile dementia," and new developments in the field, focusing on Alzheimer's disease (AD), the most prevalent cause of dementia in pathological aging. Clinical guidelines issued in 2024 by the US National Institute on Aging-Alzheimer's Association (NIA-AA) and the European Neuroscience Societies did not endorse routine use of rsEEG biomarkers in the clinical workup of older adults with cognitive impairment. Nevertheless, the expert panel highlighted decades of research from independent workgroups and different techniques showing consistent evidence that abnormalities in rsEEG delta, theta, and alpha rhythms (< 30 Hz) observed in AD patients correlate with wellestablished AD biomarkers of neuropathology, neurodegeneration, and cognitive decline. We posit that these abnormalities may reflect alterations in oscillatory synchronization within subcortical and cortical circuits, inducing cortical inhibitory-excitatory imbalance (in some cases leading to epileptiform activity) and vigilance dysfunctions (e.g., mental fatigue and drowsiness), which may impact AD patients' quality of life. Berger's vision of using EEG to understand and manage dementia in pathological aging is still actual.

Indexed as

Alpha RhythmAlzheimer DiseaseBrainElectroencephalographyHistory, 20th CenturyHumansAlzheimer’s Disease (AD)BiomarkersDelta, Theta, and Alpha RhythmsHans BergerMild Cognitive Impairment (MCI)Resting-State Electroencephalographic (rsEEG) Rhythms

Identifiers

PMID39978053
PMCPMC13137464

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