Evidence map›Paper›PMID 39977669›Full record

ReviewChemical reviews2025

The Cation-π Interaction in Chemistry and Biology.

Dennis A Dougherty

Abstract readReview
In one paragraph

Review in Chemical reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Article
  2. Article
  3. A cloaked glutamate decarboxylase sustains the GABA shunt inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Aperture-Controlled CsChemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  5. Article
  6. Design of Fuel-Dependent, Complex-Coacervate-Based Synthetic Cells.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Photodissociation Dynamics of the ZnThe journal of physical chemistry. A · 2026
    Article
  12. Article
  13. Controlling the Guanidinium Cation Rotation by Cation-π Interactions.Angewandte Chemie (International ed. in English) · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Self-Assembling Short Peptide Carriers for Gene Delivery.International journal of molecular sciences · 2026
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Dennis A DoughertyDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID 0000-0003-1464-2461

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cation-π interaction is an important noncovalent binding force that impacts all areas of chemistry and biology. Extensive computational and gas phase experimental studies have established the potential strength and the essential nature of the interaction. Previous reviews have emphasized studies of model systems and a variety of biological examples. This work includes discussion of those areas but emphasizes other areas that are perhaps less well appreciated. These include the novel cation-π binding ability of alkali metals in water; the application of the cation-π interaction to organic synthesis and chemical biology; cooperative behaviors of multiple cation-π interactions, including adhesive proteins from mussels and similar organisms and the formation and modulation of biomolecular condensates (phase separation); and cation-π interactions involved in recognizing DNA/RNA.

Indexed as

CationsAnimalsDNAMetals, AlkaliProteinsRNAWaterCationsDNAMetals, AlkaliProteinsRNAWater

Identifiers

PMID39977669
PMCPMC11907405

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.