Evidence map›Paper›PMID 39977622›Full record

ArticleACS applied bio materials2025

Antibacterial Polymers Based on Two Orthogonal Binding Motifs Coalesce with Bacterial Matter.

Esteban Bautista, Eduardo Estrada, Jacob Deyell, Melody Sun, Albert R La Spada, Seunghyun Sim

Abstract read
In one paragraph

Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Esteban BautistaDepartment of Chemistry, University of California Irvine, Irvine, California 92697, United States.
Eduardo EstradaDepartment of Chemistry, University of California Irvine, Irvine, California 92697, United States.ORCID 0009-0000-9695-4594
Jacob DeyellDepartment of Pathology & Laboratory Medicine, University of California Irvine, Irvine, California 92697, United States.
Melody SunDepartment of Chemistry, University of California Irvine, Irvine, California 92697, United States.ORCID 0009-0008-6144-8059
Albert R La SpadaDepartment of Pathology & Laboratory Medicine, University of California Irvine, Irvine, California 92697, United States.
Seunghyun SimDepartment of Chemistry, University of California Irvine, Irvine, California 92697, United States.ORCID 0000-0002-4232-5917

Funding

La Spada Outstanding Investigator AwardR35NS122140 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ALBERT R LA SPADA · 2021 to 2026
$7.2M
Spatially Structured Synthetic Consortia of Microbes to Understand and Engineer Cells in 3D EnvironmentsR35GM150770 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Seunghyun Sim · 2023 to 2026
$1.5M
The Neuroprotective Role of PPAR-delta in MicrogliaF30AG081084 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI DEYELL, JACOB SAHAG · 2023 to 2025
$161k
NIA NIH HHS F30 AG081084NIGMS NIH HHS R35 GM150770NINDS NIH HHS R35 NS122140
6 · The paper itself

Abstract

Addressing the growing concern about antibiotic-resistant bacteria, we have developed a series of polymers exhibiting intrinsic antibacterial activities with a dual-targeting system that induces physical lysis upon copolymer coalescence with bacterial matter. These polymers are equipped with two orthogonal binding motifs that form electrostatic interactions and dynamic covalent complexes on bacterial surfaces and exhibit potent antibacterial activity against Gram-positive and Gram-negative bacteria. The effect of the chemical composition and architecture of copolymers incorporating phenylboronic acid and quaternary ammonium groups on the antimicrobial activities was systematically examined. This work expands the current chemical repertoire to combat antimicrobial resistance by intrinsically antibacterial polymers with a unique mode of action.

Indexed as

Anti-Bacterial AgentsBiocompatible MaterialsPolymersBoronic AcidsEscherichia coliGram-Negative BacteriaGram-Positive BacteriaMaterials TestingMicrobial Sensitivity TestsMolecular StructureParticle SizeSurface PropertiesAnti-Bacterial AgentsBiocompatible MaterialsBoronic AcidsPolymersantibacterial polymersantimicrobial polymersbactericidal activitycopolymersself-assembly

Identifiers

PMID39977622
PMCPMC11927954

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.