ArticleScience (New York, N.Y.)2025
A neural basis for prosocial behavior toward unresponsive individuals.
Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Adolescent Social Isolation Induces Persistent Impairments in Emotional Discrimination and Helping Behavior.eNeuro · 2026Article
- Targeting dopamine transporter for treating social transmission of depression-like behaviors in male mice.Nature communications · 2026Article
- Unveiling animal death cognition: the role of social systems.Science China. Life sciences · 2026Article
- GABA signaling in NG2 glia mediates empathy-like behavior under observational social defeat.Nature communications · 2026Article
- Cooperation: Behavioral manifestations and neural mechanisms.Current opinion in neurobiology · 2026Review
- Experience-dependent modulation of prosocial touch in mice.iScience · 2026Article
- The neural control of infanticide and parental behaviors in male mice.bioRxiv : the preprint server for biology · 2026Article
- Neural correlates of adversity-overcoming pup rescue behavior in female mice.Scientific reports · 2026Article
- The Anterior Cingulate Cortex and Prosocial Behavior toward Others in Negative State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- The Cognitive-Affective Social Processing and Emotion Regulation (CASPER) model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Alleviation of negative emotional and pain responses through amygdala-hypothalamic social circuit activation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Causes of symptoms and symptom persistence in long COVID and myalgic encephalomyelitis/chronic fatigue syndrome.Cell reports. Medicine · 2025Review
- Distinct oxytocin signaling pathways synergistically mediate rescue-like behavior in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Reviving-like prosocial behavior in response to unconscious or dead conspecifics in rodents.Science (New York, N.Y.) · 2025Article
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Authors and funding
3 authors.
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Abstract
Humans often take actions to assist others experiencing unresponsiveness, such as transient loss of consciousness. How other animals react to unresponsive conspecifics-and the neural mechanisms driving such behaviors-remain largely unexplored. In this study, we demonstrated that mice exhibit rescue-like social behaviors toward unresponsive conspecifics, characterized by intense physical contact and grooming directed at the recipient's facial and mouth areas, which expedite their recovery from unresponsiveness. We identified the medial amygdala (MeA) as a key region that encodes the unresponsive state of others and drives this head-directed physical contact. Notably, the behavioral responses toward unresponsive conspecifics differed from those directed at awake, stressed individuals, and these responses were differentially represented in the MeA. These findings shed light on the neural mechanisms underlying prosocial responses toward unresponsive individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.