ArticleProceedings of the National Academy of Sciences of the United States of America2025
A novel quinone biosynthetic pathway illuminates the evolution of aerobic metabolism.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Global distribution of isoprenoid quinones across Bacteria.mSystems · 2026Article
- Oxygen reductase origin followed the great oxidation event and terminated the Lomagundi excursion.Biochimica et biophysica acta. Bioenergetics · 2026Article
- Heterologous plastoquinone production using a newly identified OThe FEBS journal · 2026Article
- Noncanonical genetic markers resolve the pre-GOE emergence of aerobic bacteria in Earth's history.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Evidence for ecological adaptation of reductive citric acid and reverse oxidative citric acid cycles based on a survey of genomes from autotrophicFEMS microbes · 2026Review
- Assessing cell survival and biosignature preservation of the extremely thermoacidophilic archaeonFEMS microbes · 2026Article
- Revisiting the greatness of Earth's great oxidation.Communications earth & environment · 2026Review
- Isotopologue Ratios IdentifyRapid communications in mass spectrometry : RCM · 2025Article
- Review
- Complete genome sequence ofMicrobiology resource announcements · 2025Article
- Quinol C-methyltransferases from extant species of early cyanobacterial lineages shed light on the emergence of plastoquinone in oxygenic phototrophs.Photosynthesis research · 2025Article
- Unusual Plastoquinones in Non-Phototrophic Nitrifying Bacteria.Environmental microbiology reports · 2025Article
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Authors and funding
21 authors.
Funding
Abstract
The dominant organisms in modern oxic ecosystems rely on respiratory quinones with high redox potential (HPQs) for electron transport in aerobic respiration and photosynthesis. The diversification of quinones, from low redox potential (LPQ) in anaerobes to HPQs in aerobes, is assumed to have followed Earth's surface oxygenation ~2.3 billion years ago. However, the evolutionary origins of HPQs remain unresolved. Here, we characterize the structure and biosynthetic pathway of an ancestral HPQ, methyl-plastoquinone (mPQ), that is unique to bacteria of the phylum
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