Evidence map›Paper›PMID 39977265›Full record

ArticleCell reports2025

Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy.

Mari Aikio, Hana M Odeh, Heike J Wobst, Bo Lim Lee, Úna Chan, Jocelyn C Mauna, Korrie L Mack, Bradley Class, Thomas A Ollerhead, Alice F Ford and 22 more

Abstract readPublished Erratum
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors.

Mari Aikio
Hana M Odeh
Heike J Wobst
Bo Lim Lee
Úna Chan
Jocelyn C Mauna
Korrie L Mack
Bradley Class
Thomas A Ollerhead
Alice F Ford
Edward M Barbieri
Ryan R Cupo
Lauren E Drake
Joshua L Smalley
Yuan-Ta Lin
Stephanie Lam
Reuben Thomas
Nicholas Castello
Ashmita Baral
Jenna N Beyer
Mohd A Najar
John Dunlop
Aaron D Gitler
Ashkan Javaherian
Julia A Kaye
George M Burslem
Dean G Brown
Christopher J Donnelly
Steven Finkbeiner
Stephen J Moss
Nicholas J Brandon
James Shorter

Funding

Defining the mechanistic basis of a prion disaggregaseR01GM099836 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SHORTER, JAMES · 2013 to 2024
$3.9M
Editing Acetylation and Protein HomeostasisR35GM142505 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI George Burslem · 2021 to 2026
$2.7M
Programming human protein disaggregases against FTDR21AG065854 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SHORTER, JAMES · 2020 to 2020
$446k
NIA NIH HHS R21 AG065854NIGMS NIH HHS R01 GM099836NIGMS NIH HHS R35 GM142505
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID39977265
PMCPMC12051464

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.