Evidence map›Paper›PMID 39977247›Full record

Observational studyEuropean journal of preventive cardiology2025

Visit-to-visit lipid variability, coronary artery calcification, inflammation, and mortality in the Multi-Ethnic Study of Atherosclerosis.

Jeffrey Shi Kai Chan, Danish Iltaf Satti, Raymond Ngai Chiu Chan, Parag Chevli, Adhya Mehta, Seth S Martin, Garima Sharma, Gary Tse, Salim S Virani, Michael D Shapiro

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of preventive cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005487 (Multi-Ethnic Study of Atherosclerosis), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00005487 active not recruitingnot on this map

Multi-Ethnic Study of Atherosclerosis (MESA)

TypeobservationalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran1999 to 2030Enrolled6,418ConditionsAtherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Artery Disease
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Jeffrey Shi Kai ChanCardiovascular Analytics Group, China-UK Collaboration, Hong Kong SAR, China.ORCID 0000-0003-0231-2393
Danish Iltaf SattiDivision of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Raymond Ngai Chiu ChanCardiovascular Analytics Group, China-UK Collaboration, Hong Kong SAR, China.ORCID 0000-0002-1678-9128
Parag ChevliCenter for Prevention of Cardiovascular Disease, Section on Cardiovascular Medicine, Wake Forest University School of Medicine, Bowman Gray Center for Medical Education, 475 Vine Street, Winston-Salem, NC 27101, USA.
Adhya MehtaDepartment of Internal Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Seth S MartinDivision of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Garima SharmaInova Heart and Vascular Institute, Inova Fairfax Medical Campus, Falls Church, VA, USA.
Gary TseCardiovascular Analytics Group, China-UK Collaboration, Hong Kong SAR, China.
Salim S ViraniThe Aga Khan University, Karachi, Pakistan.
Michael D ShapiroCenter for Prevention of Cardiovascular Disease, Section on Cardiovascular Medicine, Wake Forest University School of Medicine, Bowman Gray Center for Medical Education, 475 Vine Street, Winston-Salem, NC 27101, USA.ORCID 0000-0002-9071-3287

Funding

Hong Kong Metropolitan University RIF/2022/2.2NHLBI NIH HHS
6 · The paper itself

Abstract

aimsThis study aimed to explore relationships between visit-to-visit lipid variability, coronary artery calcification (CAC), inflammation, and long-term mortality, which may be prognostically relevant. METHODS AND

resultsThis prospective cohort study included participants from the Multi-Ethnic Study of Atherosclerosis with available plasma LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), total cholesterol (TC), and triglycerides from all three initial exams who underwent computed tomography CAC quantification at the third (index) exam. Visit-to-visit variability (coefficient of variation) was calculated from all three initial exams. Outcomes included the index Agatston score, cardiovascular mortality, all-cause mortality, and high-sensitivity C-reactive protein. Altogether, 1515 participants were analysed. Higher HDL-C variability was associated with higher index Agatston score [Quartile 4 (Q4; vs. Q1) adjusted marginal effects 0.25 0.02-0.48)], but not LDL-C, TC, and triglyceride variability. Over a 15.1-year median follow-up, higher HDL-C [Q4 vs. Q1: adjusted sub-hazard ratio 2.68 (1.61-4.48)] and TC [Q4 vs. Q1: adjusted sub-hazard ratio 2.13 (1.17-3.89)] variability, but not LDL-C and triglyceride variability, was associated with higher risk of cardiovascular mortality, which remained significant after adjusting for the index Agatston score. Additionally, higher HDL-C variability was associated with higher risk of all-cause mortality [Q4 vs. Q1: adjusted hazard ratio 1.46 (1.00-2.11)], but LDL-C, TC, and triglyceride variability were not. HDL-C [Q4 vs. Q1: adjusted β: 0.132 (0.034-0.230)] and TC [Q4 vs. Q1: adjusted β: 0.210 (0.064-0.357)] variability, but not LDL-C and triglyceride variability, may be correlated with high-sensitivity C-reactive protein.

conclusionElevated HDL-C variability was associated with greater CAC burden and long-term risks of cardiovascular and all-cause mortality. These mortality-related associations were probably not completely explainable by atherosclerosis. REGISTRATION: ClinicalTrials.gov: NCT00005487.

Indexed as

Coronary Artery DiseaseDyslipidemiasInflammationInflammation MediatorsLipidsVascular CalcificationAgedBiomarkersCholesterol, HDLC-Reactive ProteinFemaleHumansMaleMiddle AgedPrognosisProspective StudiesBiomarkersCholesterol, HDLC-Reactive ProteinInflammation MediatorsLipidsTriglyceridesAtherosclerosisCalcium scoreCoronary artery calciumC-reactive proteinInflammationLipidMESAMortalityVariability

Identifiers

PMID39977247
PMCPMC12450528

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.