ArticlePlant physiology2025
The transcription factor WRKY41-FLAVONOID 3'-HYDROXYLASE module fine-tunes flavonoid metabolism and cold tolerance in potato.
Article in Plant physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The RcDREB1E-RcMYB28 module improves drought tolerance in Rosa chinensis via RcLAR/RcCORA1-mediated proanthocyanidin biosynthesis and stress responses.The Plant journal : for cell and molecular biology · 2026Article
- Germplasm Screening and Transcriptome Profiling Identify Phenylpropanoid Biosynthesis-Related PAL Candidate Genes Associated with Freezing Tolerance in Potato.Biomolecules · 2026Article
- WRKY transcription factors in potato research: functional genetic manipulation for multi-stress resilience and crop improvement.Plant molecular biology · 2026Article
- Engineering climate-resilient horticultural crops: advances in transcriptional regulation, genome editing, and synthetic networks.Horticulture research · 2026Article
- VaWRKY26 transcription factor from Vitis amurensis negatively regulates plant cold tolerance.Planta · 2026Article
- WRKY27-RAP2.7 Regulatory Module Promotes Cold Tolerance via Modulation of Lignin Biosynthesis and Redox Homeostasis by Regulating Cinnamyl Alcohol Dehydrogenase 7 and Glutathione S-Transferase F6.Plant biotechnology journal · 2026Article
- The Transcription Factors NFYA1 and GBF3 Jointly Regulate CHS2 to Promote Tangeretin Accumulation and Cold Tolerance in Citrus.Plant biotechnology journal · 2026Article
- Research progress on cold tolerance key genes and mechanisms in four major northern China crops.Frontiers in plant science · 2026Review
- Molecular mechanisms of plant freezing tolerance: from cold signal perception to adaptive responses.Frontiers in plant science · 2026Review
- Plant responses to cold stress: molecular and physiological adaptive mechanisms with breeding advances.Frontiers in plant science · 2026Review
- Metabolomics and Transcriptomics Analyses Uncover the Potential of Flavonoids in Response to Saline-Alkali Stress inBiology · 2025Article
- Metabolomics and Transcriptomic Analysis Revealed the Response Mechanism of Maize to Saline-Alkali Stress.Plant biotechnology journal · 2025Article
- The transcription factor VaWRKY72 from Vitis amurensis positively regulates cold tolerance in Arabidopsis thaliana and grapevine.Plant molecular biology · 2025Article
- Genome-Wide Transcriptome Analysis Reveals GRF Transcription Factors Involved in Methyl Jasmonate-Induced Flavonoid Biosynthesis inPlants (Basel, Switzerland) · 2025Article
- Unraveling the signaling pathways of plant cold stress: current insights and future directions.Frontiers in plant science · 2025Review
- Spatial and Temporal Dynamics of Phenylpropanoid Pathway-Derived Secondary Metabolites Under Abiotic Stress.Physiologia plantarumReview
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9 authors.
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Abstract
Cold stress adversely affects crop growth and productivity. Resolving the genetic basis of freezing tolerance is important for crop improvement. Wild potato (Solanum commersonii) exhibits excellent freezing tolerance. However, the genetic factors underlying its freezing tolerance remain poorly understood. Here, we identified flavonoid 3'-hydroxylase (F3'H), a key gene in the flavonoid biosynthesis pathway, as highly expressed in S. commersonii compared with cultivated potato (S. tuberosum L.). Loss of ScF3'H function impaired freezing tolerance in S. commersonii, while ScF3'H overexpression in cultivated potato enhanced its freezing tolerance. Metabolic analysis revealed that F3'H generates more downstream products by adding hydroxyl (-OH) groups to the flavonoid ring structures. These flavonoids enhance reactive oxygen species scavenging, thereby contributing to freezing tolerance. Furthermore, the W-box element in the F3'H promoter plays a critical role in cold responses. Cold-induced transcription factor ScWRKY41 directly binds to the ScF3'H promoter region and recruits histone acetyltransferase 1 (ScHAC1), which enhances histone acetylation at the F3'H locus and activates its transcription. Overall, we identified the cold-responsive WRKY41-F3'H module that enhances freezing tolerance by augmenting the antioxidant capacity of flavonoids. This study reveals a valuable natural gene module for breeding enhanced freezing tolerance in potato and other crops.
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