Evidence map›Paper›PMID 39976896›Full record

ArticleJournal of neuro-oncology2025

Neurocognitive function in lower grade glioma patients selected for proton radiotherapy: real-world data from a prospective cohort study.

Hiska L van der Weide, Anne M Buunk, Femke F Siebenga, Johannes A Langendijk, Agata Bannink-Gawryszuk, Ingeborg Bosma, Roelien H Enting, Anouk van der Hoorn, Hanne-Rinck Jeltema, Michiel Wagemakers and 5 more

Abstract read
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In one paragraph

Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hiska L van der WeideDepartment of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. h.l.van.der.weide@umcg.nl.ORCID http://orcid.org/0000-0001-6734-2345
Anne M BuunkDepartment of Neurology, Unit of Neuropsychology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Femke F SiebengaDepartment of Neurology, Unit of Neuropsychology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Johannes A LangendijkDepartment of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Agata Bannink-GawryszukDepartment of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Ingeborg BosmaDepartment of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Roelien H EntingDepartment of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Anouk van der HoornDepartment of Radiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Hanne-Rinck JeltemaDepartment of Neurosurgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Michiel WagemakersDepartment of Neurosurgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Rob J M GroenDepartment of Neurosurgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Annemiek M E Walenkamp-HagemanDepartment of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Janine NuverDepartment of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Miranda C A KramerDepartment of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jacoba M SpikmanDepartment of Neurology, Unit of Neuropsychology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine neurocognitive function (NCF) profiles of patients with lower grade glioma (LGG) eligible to undergo proton radiotherapy (PRT), and how these relate to clinical and radiological characteristics. PRT is offered to those patients for whom sparing of NCF is considered important given their favorable prognosis. To date it is unknown to which extent their NCF profiles are favorable as well.

methodsA consecutive cohort of 151 LGG patients eligible for PRT according to prevailing Dutch criteria, referred between 2018 and 2023, were assessed with standardized neuropsychological tests prior to PRT. Scores were compared to norm-scores. Composite scores were calculated for the total NCF and 6 separate cognitive domains, and profiles were related to tumor location. Clinical and radiological factors characterizing overall NCF impaired patients were investigated, comparing 3 definitions for impairment.

resultsPatients had on average significantly lower NCF than their norm-group, but interindividual variability was large. For 100/151 patients (66.2%), all cognitive domains were intact, whereas 15/151 patients (9.9%) displayed multiple domain impairments. Poorer NCF was related to right-sided LGG laterality, larger PRT target volume, no Wait & Scan policy, worse neurological function and worse radiological indices (Fazekas and global cortical atrophy, respectively). LGG involvement of the left temporal and occipital lobes was associated with, respectively, lower verbal memory and processing speed.

conclusionPrior to PRT, the majority of selected LGG patients display favorable NCF profiles. However, a subgroup showed NCF impairments, with multiple relevant clinical and radiological covariates.

Indexed as

Brain NeoplasmsCognitionCognitive DysfunctionGliomaProton TherapyAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm GradingNeuropsychological TestsPrognosisProspective StudiesLow grade gliomaNeurocognitive functionProton therapyRadiotherapy

Identifiers

PMID39976896
PMCPMC12041185

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.