Evidence map›Paper›PMID 39976893›Full record

SynthesisInternational urology and nephrology2025

Analysis of gut microbiota variations in patients with Henoch-Schönlein purpura: a comprehensive systematic review.

Khaled Saad, Muhammad Abd-Ellatif, Nehal E Abdel-Hakem, Abdelrahman Ali, Osama Ahmed Khalil, Tasbih Emad, Omar Abo-Gazia, Asmaa Eldamaty, Yusof M Omar, Mohammad Alzu'bi and 9 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Khaled Saad *Pediatric Department, Faculty of Medicine, Assiut University, Assiut, 71516, Egypt. Khaled.ali@med.au.edu.eg.
Muhammad Abd-Ellatif *Faculty of Pharmacy, Al Azhar University, Assiut, Egypt.
Nehal E Abdel-HakemGenetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City (USC), Sadat City, Egypt.
Abdelrahman AliFaculty of Medicine, Minia University, Minia, Egypt.
Osama Ahmed KhalilFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Tasbih EmadFaculty of Physical Therapy, Cairo University, Cairo, Egypt.
Omar Abo-GaziaFaculty of Medicine, Al-Azhar University, New Damietta Branch, Damietta, Egypt.
Asmaa EldamatyFaculty of Medicine, Cairo University, Cairo, Egypt.
Yusof M OmarFaculty of Medicine, Mansoura University, Mansoura, Egypt.
Mohammad Alzu'biFaculty of Medicine, Hashemite University, Zarqa, Jordan.
Mohammad BazzazehFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Ahmed AfifiUniversity of Texas MD Anderson Cancer Center, Houston, USA.
Amira H El-AshryMedical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Sherin A TahaPediatric Department, Faculty of Medicine, Suez University, Suez, Egypt.
Hoda Atef Abdelsattar IbrahimPediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Thamer AlruwailiDepartment of Pediatrics, College of Medicine, Jouf University, Sakaka, Saudi Arabia.
Amira ElhoufeyDepartment of Community Health Nursing, Alddrab University College, Jazan University, 45142, Jazan, Saudi Arabia.
Hamad Ghaleb DailahResearch and Scientific Studies Unit, College of Nursing, Jazan University, Jazan, Saudi Arabia.
Anas ElgenidyFaculty of Medicine, Cairo University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe primary purpose of our study was to perform a comprehensive systematic review, aiming to bring out the association between gut microbiota, Henoch-Schönlein Purpura (HSP) and Henoch-Schönlein nephritis (HSPN) patients.

methodsA systematic review was performed using five electronic databases, including Medline (through PubMed), Scopus, Embase, Cochrane, and Web of Science, from inspection up to March 21, 2024, to detect the studies that assessed the gut microbiota variation in Henoch-Schönlein Purpura (HSP) and Henoch-Schönlein nephritis (HSPN) patients.

resultsMicrobial diversity, richness, and composition in HSP patients are decreased compared to the healthy control group. In addition, HSP patients display a different microbiota structure and show a significant difference in taxonomic abundance between HSP and health control, which differs from one level to another. At the phylum level, Bacteroidetes, Fusobacteria, and Blastocladiomycota were more abundant; at the class level, Bacteroidetes were more abundant; at the order level, Bacteroidetes were more abundant in the HSP group-stage and site of HSP involvement effect on microbiota. Gastrointestinal tract involvement is characterized by increased abundance of Streptococcus and Fusobacteria and a decrease in Faecalibacterium. Kidney involvement is characterized by increased abundance of Streptococcus spp, which can be used as an indicator of disease severity. Escherichia-Shigella can be used as a diagnostic for the recurrence of HSP because its abundance is higher than primary HSP.

conclusionGut microbiota can be utilized to assess the severity, recurrence, and site of HSP infection by analyzing the diversity, richness, and abundance of specific microorganisms associated with the condition.

Indexed as

Gastrointestinal MicrobiomeIgA VasculitisNephritisHumansGut microbiotaHenoch–Schönlein nephritisHenoch–Schönlein purpura

Identifiers

PMID39976893

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.