ArticleScience China. Life sciences2025
Low-dose exposure to microplastics retards meiotic maturation via HDAC3 insufficiency.
Article in Science China. Life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- CPEB1 orchestrates cell cycle-dependent translation of maternal factors to coordinate nuclear-cytoplasmic maturation in porcine oocytes.Science China. Life sciences · 2026Article
- Ovarian toxic effects of micro- and nanoplastics (Review).Experimental and therapeutic medicine · 2026Review
- Microplastics in early-onset carcinogenesis.Carcinogenesis · 2026Review
- Article
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Authors and funding
12 authors.
Funding
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Abstract
Microplastics (MPs) are considered one of the main causes of male and female infertility. However, the reproductive toxicity and its related mechanisms are currently understood primarily through animal models with acute exposure to MPs. In this study, we demonstrate that low-dose exposure to polystyrene microplastics (PSMPs) leads to severely abnormal reproduction in females, manifested by oocyte meiotic maturation defect. Mechanistically, PSMPs exposure induce the overactivation of cell metabolism pathways, insufficient HDACs, and H4K16 hyperacetylation in oocytes both in vivo and in vitro. When an HDAC3 inhibitor is added, the oocyte maturation defect, overactivation of cell metabolism pathways, and H4K16 hyperacetylation are recapitulated. Conversely, the overexpression of HDAC3 can rescue the defects in meiotic maturation induced by PSMPs. Our observations suggest a direct link between the maturation defects caused by PSMPs and HDAC3 insufficiency. Thus, we propose potential treatments to address the meiotic maturation defect of oocytes in women highly exposed to MPs by activating or supplying HDAC3.
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Registered trials
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