Evidence map›Paper›PMID 39976830›Full record

ArticleDigestive diseases and sciences2025

Annual Blood Tests Are an Acceptable form of Surveillance to Supplement Colonoscopies for Colorectal Cancer.

Rishabh Goyal, Carlene J Wilson, Ingrid H Flight, Charles Cock, Graeme P Young, Molla M Wassie, Sarah Cohen-Woods, Erin L Symonds, Maddison Dix

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rishabh GoyalDepartment of Medicine, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Carlene J WilsonFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Ingrid H FlightFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Charles CockFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Graeme P YoungFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Molla M WassieFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Sarah Cohen-WoodsFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Erin L SymondsFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Maddison DixFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia. maddison.dix@flinders.edu.au.

Funding

National Health and Medical Research Council 2009050
6 · The paper itself

Abstract

backgroundIndividuals at increased risk of colorectal cancer (CRC) are recommended surveillance colonoscopies as a preventative measure, but timely provision of colonoscopies remains a significant hurdle. Biomarker testing has emerged as a potential strategy to mitigate excessive colonoscopy use by prioritizing procedures for those most at risk of CRC. However, the acceptability of supplementing surveillance colonoscopies with regular blood tests is unknown.

aimTo evaluate patient acceptance of a hypothetical surveillance protocol providing annual blood tests between 5-yearly colonoscopies.

methodsEight hundred individuals enrolled in an Australian surveillance colonoscopy program were invited to complete a survey on surveillance preferences. Ordinal logistic regression analysis was performed to assess the influence of sociodemographic, clinical, and psychological variables on participants' comfort with the surveillance protocol.

resultsA total of 409 (51%) individuals participated, with 346 (51% male, mean age 63 years) providing complete outcome data. Most participants (n = 250/346, 72%) reported being comfortable with the surveillance protocol. Significantly higher levels of comfort were reported by individuals with greater confidence in their ability to undergo blood testing (OR 1.26, 95% CI 1.08-1.47, p = 0.003) and those having less frequent surveillance colonoscopies (OR 1.26, 95% CI 1.01-1.58, p = 0.043). Significant associations were not observed between other variables and comfort with the surveillance protocol (p > 0.05).

conclusionsAnnual blood testing between surveillance colonoscopies was highly accepted by individuals at increased risk of CRC. Offering new blood-based modalities to specific subpopulations, particularly individuals who are more comfortable with blood testing, or those having less frequent surveillance colonoscopies, could enhance overall acceptance.

Indexed as

ColonoscopyColorectal NeoplasmsEarly Detection of CancerHematologic TestsPatient Acceptance of Health CareAgedAustraliaFemaleHumansMaleMiddle AgedOccult BloodPopulation SurveillanceBlood testColonoscopyColorectal neoplasiaEarly detection of cancerPatient preferencePopulation surveillance

Identifiers

PMID39976830
PMCPMC11972185

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.