Evidence map›Paper›PMID 39976794›Full record

ArticleParasitology research2025

In vitro analysis of the activities of commercial anthelmintics in the presence of inhibitors of xenobiotic detoxification pathways in Haemonchus contortus exsheathed L3 stage.

Magdalena Nieves, Gerardo Duarte, Jenny Saldaña, María Elisa Melian, Beatriz Munguía

Abstract read
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Article in Parasitology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Magdalena NievesÁrea de Farmacología, CIENFAR, Facultad de Química, Universidad de La República, Montevideo, Uruguay.
Gerardo DuarteÁrea de Farmacología, CIENFAR, Facultad de Química, Universidad de La República, Montevideo, Uruguay.
Jenny SaldañaÁrea de Farmacología, CIENFAR, Facultad de Química, Universidad de La República, Montevideo, Uruguay.
María Elisa MelianÁrea de Farmacología, CIENFAR, Facultad de Química, Universidad de La República, Montevideo, Uruguay.
Beatriz MunguíaÁrea de Farmacología, CIENFAR, Facultad de Química, Universidad de La República, Montevideo, Uruguay. munguia@fq.edu.uy.

Funding

Comisión Sectorial de Investigación Científica de la Universidad de la República Research project 366CSIC - Udelar for the Posgraduate scholarship BDMX_2023_1#49499052
6 · The paper itself

Abstract

Haemonchus contortus is a pathogenic nematode that infects small ruminants. Chemotherapy is the main treatment for these parasitic infections, but the rapid rise of drug resistance calls for the development of new anthelmintics. To support this, optimizing screening assays is vital for identifying new drugs. The exsheathed L3 (xL3) stage of H. contortus is often used in in vitro evaluations; however, it has been observed that it is less sensitive than the adult stage, possibly due to enhanced detoxification pathways. To explore this hypothesis, inhibitors of xenobiotic detoxification pathways were tested on the activity (IC

Indexed as

AnthelminticsHaemonchusXenobioticsAlbendazoleAminoacetonitrileAnimalsInactivation, MetabolicInhibitory Concentration 50IvermectinLarvaLevamisoleAlbendazolealbendazole sulfoxideAminoacetonitrileAnthelminticsIvermectinLevamisolemonepantelXenobioticsAutomated motility assayDetoxification pathwaysHaemonchus contortusXenobiotics

Identifiers

PMID39976794
PMCPMC11842493

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.