ArticleWorld journal of urology2025
Is it necessary for patients with a positive urine culture to achieve a negative result after antimicrobial treatment before undergoing percutaneous nephrolithotomy?
Article in World journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Systemic inflammatory response syndrome in pediatric urinary tract infections associated with urolithiasis: a retrospective study of risk factors, pathogens, and antimicrobial resistance at two tertiary hospitals.BMC infectious diseases · 2026Article
- Comparison of preoperative and intraoperative cultures for predicting postoperative urinary tract infections following supine PCNL.World journal of urology · 2026Article
- Can dynamic changes in preoperative urinary white blood cells and nitrite predict infectious complications after percutaneous nephrolithotomy in culture-positive patients?World journal of urology · 2026Observational
- Preoperative Urine Testing in Elective Endourology Procedures: Is a Change in Practice the Need of the Hour?Cureus · 2025Article
- Article
- New advances in efficacy prediction of extracorporeal shock wave lithotripsy in pediatrics: a narrative review.Frontiers in pediatrics · 2025Review
- Positive preoperative urine culture is a predictor of urinary tract infections and fever following suction mini-PCNL: results from a large, multicenter series from the Endourology section of the European Association of Urology and the STUMPS collaborative group.Therapeutic advances in urologyArticle
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11 authors.
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Abstract
objectiveThere is ongoing debate regarding whether patients with a positive urine culture (UC) need to wait for the culture to turn negative following antimicrobial treatment before undergoing percutaneous nephrolithotomy (PCNL). This study aimed to evaluate the necessity of achieving a negative UC before PCNL and its association with postoperative systemic inflammatory response syndrome (SIRS) and sepsis.
methodsThis prospective study included 147 patients with positive UCs who underwent PCNL at The First Affiliated Hospital of Guangzhou Medical University from March 2021 to April 2024. Patients were treated with sensitive antibiotics for 5-7 days based on the susceptibility results of their initial UC. Follow-up UCs were performed on day 3 after starting antibiotics and immediately before surgery. The relationship between UC results and postoperative infectious complications, including SIRS and sepsis, was analyzed. Multivariable analysis was conducted to identify independent risk factors.occurrence of postoperative infectious complications, including SIRS and sepsis, was analyzed. Multivariable analysis was used to identify independent risk factors.
resultsAmong the 147 patients, 133 (90·5%) had a negative urine culture on day 3 of treatment, while 14 remained positive. Preoperatively, 136 patients (92·5%) had negative UCs. Univariate analysis showed no significant differences in the incidence of postoperative systemic inflammatory response syndrome (SIRS) and sepsis between the UC-negative and UC-positive groups on day 3 and preoperatively (p > 0·05). Multivariable analysis identified stone burden (OR 1·01, 95% CI 1·01-1·01, p = 0·009), multiple access tracts (OR 2·64, 95% CI 1·08 - 6·45, p = 0·034), and positive stone cultures (OR 5·03, 95% CI 1·84 - 13·74, p = 0·002) as independent risk factors for postoperative SIRS. Bacterial variations were observed in follow-up UCs from 8 patients, but these did not impact postoperative complications.
conclusionAchieving a negative UC before PCNL is not a necessary condition. Patients with positive UCs can safely undergo surgery after 5 days or more of sensitive antibiotic treatment without the need for a negative UC result. Positive stone cultures are valuable predictors of postoperative SIRS, supporting the routine collection of stone culture specimens.
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