Evidence map›Paper›PMID 39976716›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2025

Cinobufagin: Unveiling the hidden bufadienolide's promise in combating alimentary canal cancer development and progression - a comprehensive review.

Beatriz Leme Boaro, Enzo Pereira de Lima, Durvanei Augusto Maria, Rose Eli Grassi Rici, Adriano Cressoni Araújo, Elen Landgraf Guiguer, Eliana de Souza Bastos Mazuqueli Pereira, Caroline Barbalho Lamas, Claudia Rucco Penteado Detregiachi, Adriana Maria Ragassi Fiorini and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Beatriz Leme Boaro *Department of Biochemistry and Pharmacology, School of Medicine, Faculdade de Medicina de Marília (FAMEMA), Marília, SP, 17519-030, Brazil.
Enzo Pereira de Lima *Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília, SP, 17525-902, Brazil.
Durvanei Augusto MariaDevelopment and Innovation Laboratory, Butantan Institute, São Paulo, SP, 05585-000, Brazil.
Rose Eli Grassi RiciPostgraduate Program in Structural and Functional Interactions in Rehabilitation, School of Medicine, Universidade de Marília (UNIMAR), Marília, SP, 17525-902, Brazil.
Adriano Cressoni AraújoDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília, SP, 17525-902, Brazil.
Elen Landgraf GuiguerDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília, SP, 17525-902, Brazil.
Eliana de Souza Bastos Mazuqueli PereiraDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília, SP, 17525-902, Brazil.
Caroline Barbalho LamasDepartment of Gerontology, School of Gerontology, Universidade Federal de São Carlos (UFSCar), São Carlos, SP, 13565-905, Brazil.
Claudia Rucco Penteado DetregiachiDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília, SP, 17525-902, Brazil.
Adriana Maria Ragassi FioriniDepartment of Biochemistry and Nutrition, School of Food and Technology of Marília (FATEC), Marília, SP, 17500-000, Brazil.
Antonely de Cássio Alves de CarvalhoDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília, SP, 17525-902, Brazil.
Lucas Fornari Laurindo *Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília, SP, 17525-902, Brazil. lucasffffor@gmail.com.
Sandra Maria Barbalho *Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília, SP, 17525-902, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cinobufagin (CB) is a bufadienolide extracted from the parotid gland of frogs. This compound is a Na

Indexed as

Antineoplastic AgentsBufanolidesGastrointestinal NeoplasmsAnimalsApoptosisCell ProliferationDisease ProgressionHumansSignal TransductionAntineoplastic AgentsBufanolidescinobufaginApoptosisBufadienolideCell cycle arrestCinobufaginColorectal cancerEsophagus cancerGastric cancerMetastasisMolecular pathwaysOral cancer

Identifiers

PMID39976716

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.