ArticleEuropean journal of nuclear medicine and molecular imaging2025
Impact of myocardial scar burden on microvascular resistance reserve in patients with coronary artery disease.
Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Impact of Prior Myocardial Infarction on Outcomes Following Multiple Arterial Coronary Bypass Grafting: A Propensity-Matched Analysis.Journal of cardiovascular development and disease · 2026Article
- Homogeneity of the coronary microcirculation in angina with non-obstructive coronary artery disease.European heart journal. Cardiovascular Imaging · 2025Article
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Authors and funding
13 authors.
Funding
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Abstract
purposeThe impact of myocardial scar on coronary microcirculation is not well understood. This study aims to evaluate the association between microvascular resistance reserve (MRR) and scar tissue.
methodsIn this post-hoc analysis of the PACIFIC 2 trial, symptomatic patients with prior myocardial infarction (MI) and/or percutaneous coronary intervention (PCI) underwent [
resultsThe study included 154 patients with 397 vessels with a mean MRR of 3.56 ± 1.24. Patients with any scar tissues (LGE > 0%) exhibited a lower MRR in every myocardial territory than those without scar tissues. After adjusting for cardiovascular risk factors, either vessel LGE burden (β =-0.013, P = 0.006) or total LGE burden (β =-0.039, P = 0.002) independently predicted a reduced MRR. Compared to myocardial territories without scar tissues (LGE burdens = 0%), MRR was significantly lower in myocardial territories with vessel LGE burden = 0% + total LGE burden > 0%, and in myocardial territories with both LGE burdens > 0%.
conclusionScar burden was negatively associated with MRR in patients with prior MI and/or PCI. Our findings indicate that both the proportion of myocardial scar in the vascular territory and the overall myocardial scar affect the microcirculation of individual vascular territories. CLINICAL TRIAL NUMBER: Not applicable.
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