Evidence map›Paper›PMID 39976612›Full record

ArticleMicrobiology (Reading, England)2025

Linking volatile metabolites from bacterial pathogens to exhaled breath condensate of people with cystic fibrosis.

P Hansani Karunarathne, Christopher Bridges, Lacy Remisoski, Madisen Crane, Claudia Soria Casanova, Samantha N Kinne, Alicia L Castillo Bahena, Marissa Gil, Lienwil Padillo, Gabriel Querido and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology (Reading, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

P Hansani KarunarathneDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
Christopher BridgesDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
Lacy RemisoskiDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
Madisen CraneDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
Claudia Soria CasanovaDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
Samantha N KinneCorewell Health, Grand Rapids, MI, USA.
Alicia L Castillo BahenaCorewell Health, Grand Rapids, MI, USA.
Marissa GilDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Lienwil PadilloDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Gabriel QueridoDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Jenna MielkeDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Marc McClellandCorewell Health, Grand Rapids, MI, USA.
Doug ConradDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Robert A QuinnDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.

Funding

Determining How a Dynamic Microbiome Contributes to Cystic Fibrosis Lung DiseaseR01AI145925 · NIAID · MICHIGAN STATE UNIVERSITY · PI QUINN, ROBERT ANDREW · 2019 to 2022
$2.7M
NIAID NIH HHS R01 AI145925
6 · The paper itself

Abstract

Obtaining sputum samples from people with cystic fibrosis (pwCF) for microbiology has become challenging due to the positive clinical effects of the cystic fibrosis transmembrane conductance regulator modulator therapy, elexacaftor-tezacaftor-ivacaftor (ETI). Although ETI improves lung function and reduces sputum production, recent data shows that bacterial pathogens persist, making continued monitoring of infection important. As an alternative to sputum sampling, this study developed a non-invasive technique called 'Cough Breath' (CB) to identify volatile organic compounds (VOCs) in exhaled breath condensate (EBC) and link them to cystic fibrosis (CF) bacterial pathogens using purge and trap GC-MS. The CB culturing approach was able to isolate pathogens from expectorated particulates simultaneously with EBC collection; however, culturing positivity was low, with 6% of samples collected (

Indexed as

BacteriaCystic FibrosisVolatile Organic CompoundsAdultBreath TestsFemaleGas Chromatography-Mass SpectrometryHumansMalePseudomonas aeruginosaSputumYoung AdultVolatile Organic Compoundscough breathcystic fibrosisexhaled breath condensatepathogensvolatile organic compounds

Identifiers

PMID39976612
PMCPMC12282304

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.