Trial reportNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2025
Change in Cigarette, Other Tobacco Product, and Cannabis Use Among Individuals Who Used or Did Not Use Cannabis During a Smoking Cessation Trial.
Trial report in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03897439 (Individualizing Pharmacotherapy), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Individualizing Pharmacotherapy: A Novel Optimization Strategy to Increase Smoking Cessation in the African American Community
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Authors and funding
7 authors.
Funding
Abstract
introductionAs many as 40% of adults who smoke (AWS) use cannabis, yet little is known about how cigarette-cannabis (CIG-CAN) use impacts change in cigarette and other tobacco product (OTP) use during a quit attempt.
methodsSecondary data analysis of a smoking cessation randomized clinical trial (RCT) that enrolled 392 Black adults who wanted to quit cigarettes and were provided 18 weeks of standard or adapted pharmacotherapy. Participants self-reported cigarettes, cannabis, and OTP at W0, 2, 6, 12, 18, and 26. Longitudinal modeling of group, time, and group by time effects compared change in cigarettes, cannabis, and OTP between those who did and did not use cannabis.
resultsNearly half (47.2%,185/392) were CIG-CAN users. Cannabis types were joints (78.4%) and blunts (51.9%). Significant reduction in CPD over time (p = .02) did not differ by group (p = .18). OTP had significant group, group by time interaction and time effect (p < .001), however, OTP use is small and had minimal effect on consumption. CIG-CAN increased cannabis use through week 26 (p < .001). When CPD decreased, there was a compensatory effect on OTP (< .0001), but not cannabis (p = .37).
conclusionPrevalence of cannabis use was high among Black adults attempting to quit cigarette smoking in an RCT. OTP use was minimal, but CIG-CAN maintained higher OTP and increased consumption of cannabis while having similar reductions in CPD. Findings require replication in a prospectively designed study but suggest a pattern of compensation, primarily with cannabis, among CIG-CAN that may limit potential health benefit of cigarette reduction and could compromise future attempts at cessation.Trial registration: NCT03897439.
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