Evidence map›Paper›PMID 39976580›Full record

ArticleAging2025

Transcriptomic landscape of cumulus cells from patients <38 years old with a history of poor ovarian response (POR) treated with platelet-rich plasma (PRP).

Leah M Roberts, Nola Herlihy, Andres Reig, Shiny Titus, Rolando Garcia-Milian, James Knight, Raziye Melike Yildirim, Cheri K Margolis, Yigit Cakiroglu, Bulent Tiras and 3 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07376460 (Biological and Proteomic Characterisation of Platelet-rich Plasma), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07376460 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Biological and Proteomic Characterisation of Platelet-rich Plasma (PRP) Before and After Mobilisation of Haematopoietic Stem Cells in Peripheral Blood From Women With Low Ovarian Response (Low Responders) and in Vitro Evaluation in Human Ovarian Cell Models

TypeobservationalSponsorInstituto Valenciano de Infertilidad, IVI AlicanteRan2026 to 2026Enrolled10ConditionsPoor Ovarian Response, Ovarian ReactivationArmsPlatelet Rich Plasma + BMDSCs mobilization
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Leah M RobertsIVIRMA Global Research Alliance, IVIRMA New Jersey, Basking Ridge, NJ 07920, USA.
Nola HerlihyIVIRMA Global Research Alliance, IVIRMA New Jersey, Basking Ridge, NJ 07920, USA.
Andres ReigIVIRMA Global Research Alliance, IVIRMA New Jersey, Basking Ridge, NJ 07920, USA.
Shiny TitusIVIRMA Global Research Alliance, IVIRMA New Jersey, Basking Ridge, NJ 07920, USA.
Rolando Garcia-MilianBioinformatics Support Hub, Cushing/Whitney Medical Library, Yale School of Medicine, New Haven, CT 06520, USA.
James KnightYale Center for Genome Analysis, Yale University, New Haven, CT 06520, USA.
Raziye Melike YildirimDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06520, USA.
Cheri K MargolisIVIRMA Global Research Alliance, IVIRMA New Jersey, Basking Ridge, NJ 07920, USA.
Yigit CakirogluDepartment of Obstetrics and Gynecology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Bulent TirasDepartment of Obstetrics and Gynecology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Christine V WhiteheadIVIRMA Global Research Alliance, IVIRMA New Jersey, Basking Ridge, NJ 07920, USA.
Marie D WernerIVIRMA Global Research Alliance, IVIRMA New Jersey, Basking Ridge, NJ 07920, USA.
Emre SeliIVIRMA Global Research Alliance, IVIRMA New Jersey, Basking Ridge, NJ 07920, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intraovarian injection of autologous platelet-rich plasma (PRP) has recently been investigated as a potential treatment for patients with diminished ovarian reserve. In the current study, differential gene expression in cumulus cells obtained from patients treated with PRP was compared to controls. RNA sequencing libraries were constructed from the cumulus cells, and differential expression analysis was performed with a false discovery rate threshold of

Indexed as

Cumulus CellsInfertility, FemaleOvarian ReservePlatelet-Rich PlasmaTranscriptomeAdultFemaleGene Expression ProfilingHumansPregnancydiminished ovarian reserveplasma rich proteinRNA-sequencing

Identifiers

PMID39976580
PMCPMC11892918

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.