Evidence map›Paper›PMID 39976443›Full record

ArticlemBio2025

Conserved lipid-facing basic residues promote the insertion of the porin OmpC into the

Janine H Peterson, Lixinhao Yang, James C Gumbart, Harris D Bernstein

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Janine H PetersonGenetics and Biochemistry Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Lixinhao YangSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA.
James C GumbartSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA.ORCID 0000-0002-1510-7842
Harris D BernsteinGenetics and Biochemistry Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-4941-3741

Funding

Elucidating the mechanisms of protein secretion across the outer membrane by bacterial autotransportersR01GM148586 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI James C. Gumbart · 2023 to 2026
$1.8M
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Intramural ResearchHHS | NIH | National Institute of General Medical Sciences (NIGMS) R01-GM148586National Science Foundation (NSF) 2138259, 2138286, 2138307, 2137603, 2138296NIDDK NIH HHS Intramural ResearchNIGMS NIH HHS R01 GM148586
6 · The paper itself

Abstract

Almost all integral membrane proteins that reside in the outer membrane (OM) of gram-negative bacteria contain a closed amphipathic β sheet ("β barrel") that serves as a membrane anchor. The membrane integration of β barrel structures is catalyzed by a highly conserved heterooligomer called the

Indexed as

Bacterial Outer MembraneBacterial Outer Membrane ProteinsEscherichia coliEscherichia coli ProteinsPorinsLipopolysaccharidesMolecular Dynamics SimulationBacterial Outer Membrane ProteinsEscherichia coli ProteinsLipopolysaccharidesOmpC proteinPorinsbarrel assembly machineryEscherichia colilipopolysaccharideouter membranetrimeric porins

Identifiers

PMID39976443
PMCPMC11898585

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.