ArticleInfection and immunity2025
Estrogen prevented gingival barrier injury from
Article in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of menopause on clinical periodontal outcomes: a systematic review.Clinical oral investigations · 2026Pooled it
- The Burden and Projections for 2036 of Periodontal Diseases in Asia From 1990 to 2021.International dental journal · 2026Article
- Sex, Gender and Sexuality in Oral Health Research: Setting the Scene.Advances in dental research · 2026Article
- Unraveling the enigma of salivary uric acid in periodontitis: Independent association, mechanistic insights, and future trajectories.World journal of clinical cases · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The postmenopausal population usually suffers from more severe periodontal disease than non-menopausal women due to the decrease and low levels of estrogen, especially β-estradiol (E2). While additional estrogen therapy can effectively relieve alveolar bone resorption, this suggests that estrogen has played an important role in the development of periodontitis. The integrity of the gingival epithelial barrier plays a key role in protecting gingival tissue from inflammatory injury caused by pathogens. However, it remains unclear whether estrogen can maintain the integrity of the gingival epithelial barrier to reduce inflammatory injury. Here, using an infection model established with
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.