Evidence map›Paper›PMID 39976355›Full record

ArticleJournal of medicinal chemistry2025

Structure and Dynamics of Macrophage Infectivity Potentiator Proteins from Pathogenic Bacteria and Protozoans Bound to Fluorinated Pipecolic Acid Inhibitors.

Victor Hugo Pérez Carrillo, Jacob J Whittaker, Christoph Wiedemann, Jean-Martin Harder, Theresa Lohr, Anil K Jamithireddy, Marina Dajka, Benedikt Goretzki, Benesh Joseph, Albert Guskov and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Victor Hugo Pérez CarrilloFaculty of Chemistry and Earth Sciences, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, 07743 Jena, Germany.
Jacob J WhittakerGroningen Institute for Biomolecular Sciences and Biotechnology, University of Groningen, 9747AG Groningen, The Netherlands.ORCID 0000-0001-8966-111X
Christoph WiedemannFaculty of Chemistry and Earth Sciences, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, 07743 Jena, Germany.ORCID 0000-0003-4351-8857
Jean-Martin HarderFaculty of Chemistry and Earth Sciences, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, 07743 Jena, Germany.ORCID 0000-0002-2322-5371
Theresa LohrInstitute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Anil K JamithireddyLiving Systems Institute, University of Exeter, Stocker Road, EX4 4QD Exeter, U.K.ORCID 0009-0009-8725-3927
Marina DajkaDepartment of Physics, Free University of Berlin, 14195 Berlin, Germany.
Benedikt GoretzkiFaculty of Chemistry and Earth Sciences, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, 07743 Jena, Germany.
Benesh JosephDepartment of Physics, Free University of Berlin, 14195 Berlin, Germany.ORCID 0000-0003-4968-889X
Albert GuskovGroningen Institute for Biomolecular Sciences and Biotechnology, University of Groningen, 9747AG Groningen, The Netherlands.ORCID 0000-0003-2340-2216
Nicholas J HarmerLiving Systems Institute, University of Exeter, Stocker Road, EX4 4QD Exeter, U.K.ORCID 0000-0002-4073-0505
Ulrike HolzgrabeInstitute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.ORCID 0000-0002-0364-7278
Ute A HellmichFaculty of Chemistry and Earth Sciences, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, 07743 Jena, Germany.ORCID 0000-0001-7162-285X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophage infectivity potentiator (MIP) proteins, found in pro- and eukaryotic pathogens, influence microbial virulence, host cell infection, pathogen replication, and dissemination. MIPs share an FKBP (FK506 binding protein)-like prolyl-

Indexed as

Bacterial ProteinsLegionella pneumophilaPipecolic AcidsTrypanosoma cruziBurkholderia pseudomalleiCrystallography, X-RayHalogenationModels, MolecularPeptidylprolyl IsomeraseProtozoan ProteinsBacterial ProteinsMip protein, Legionella pneumophilaPeptidylprolyl IsomerasePipecolic AcidsProtozoan Proteins

Identifiers

PMID39976355
PMCPMC11912469

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.