Evidence map›Paper›PMID 39976315›Full record

Trial reportExperimental physiology2026

Impact of exercise training on tumour-infiltrating T cells in human prostate cancer: A secondary analysis of a randomized controlled trial (PRO-TEST).

Simon Nørskov Thomsen, Emil Wriedt, Marianne Gardar Stærk, Sissal Sigmundsdottir Djurhuus, Birgitte Grønkær Toft, Sabrina Wielsøe, Andreas Røder, Thomas Hasselager, Peter Busch Østergren, Henrik Jakobsen and 4 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Observational
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Simon Nørskov ThomsenCentre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Emil WriedtDepartment of Endocrinology, Hvidovre University Hospital, Hvidovre, Denmark.
Marianne Gardar StærkDepartment of Pathology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Sissal Sigmundsdottir DjurhuusCentre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-8879-3644
Birgitte Grønkær ToftDepartment of Pathology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Sabrina WielsøeCentre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Andreas RøderDepartment of Urology, Copenhagen Prostate Cancer Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Thomas HasselagerDepartment of Pathology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.
Peter Busch ØstergrenDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Henrik JakobsenDepartment of Urology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-4753-8807
Klaus BrassoDepartment of Pathology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Jesper Frank ChristensenCentre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Louise Lang LehrskovCentre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-1947-4252
Casper SimonsenCentre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-2365-9978

Funding

Lundbeck FoundationTrygFonden ID101390TrygFonden ID125132TrygFonden ID177225TrygFonden ID20045
6 · The paper itself

Abstract

Exercise training reduces tumour growth by increasing tumour-infiltrating T-cell density in preclinical models. However, it remains unknown whether exercise training can modify intratumoural T cells in humans.The aim of this study was to compare the effects of an exercise training intervention versus control on human prostate intratumoural T-cell density.This study is a secondary analysis of a randomized controlled trial. We randomly allocated men (age > 18 years) with treatment-naive localized prostate cancer scheduled for radical prostatectomy 2:1 to exercise training intervention or control. The exercise intervention consisted of supervised, high-intensity interval bicycling four times per week from the time of randomization until prostatectomy. Intratumoural CD3

Indexed as

ExerciseLymphocytes, Tumor-InfiltratingProstatic NeoplasmsT-LymphocytesAgedCD3 ComplexCD8-Positive T-LymphocytesHumansMaleMiddle AgedProstateProstatectomyCD3 Complexexerciseprostate cancerT cells

Identifiers

PMID39976315
PMCPMC13238682

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.