Evidence map›Paper›PMID 39976271›Full record

ArticleTherapeutic delivery2025

Nystatin:β-cyclodextrin and chlorhexidine:β-cyclodextrin mucoadhesive hydrogels for site-specific buccal applications.

Amanda Aparecida Maia Neves Garcia, Juliana Aenishanslin, Carolina Yoshi Campos Sugio, Thais Letícia Moreira da Silva, Vanessa Migliorini Urban, Marina Tolentino Marinho, Benjamim de Melo Carvalho, Karin Hermana Neppelenbroek, Priscileila Colerato Ferrari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic delivery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amanda Aparecida Maia Neves GarciaDepartment of Prosthodontics and Periodontics, Bauru School of Dentistry, University of São Paulo (USP), Bauru, Brazil.ORCID 0000-0002-9774-1010
Juliana AenishanslinDepartment of Pharmaceutical Sciences, State University of Ponta Grossa (UEPG), Ponta Grossa, Brazil.ORCID 0000-0003-0679-9514
Carolina Yoshi Campos SugioDepartment of Prosthodontics and Periodontics, Bauru School of Dentistry, University of São Paulo (USP), Bauru, Brazil.ORCID 0000-0001-8934-4472
Thais Letícia Moreira da SilvaDepartment of Pharmaceutical Sciences, State University of Ponta Grossa (UEPG), Ponta Grossa, Brazil.ORCID 0000-0003-0001-2602
Vanessa Migliorini UrbanDepartment of Dentistry, State University of Ponta Grossa (UEPG), Ponta Grossa, Brazil.ORCID 0000-0003-3320-8783
Marina Tolentino MarinhoDepartment of Food Engineering, State University of Ponta Grossa (UEPG), Ponta Grossa, Brazil.ORCID 0000-0002-4734-6856
Benjamim de Melo CarvalhoDepartment of Materials Engineering, State University of Ponta Grossa (UEPG), Ponta Grossa, Brazil.ORCID 0000-0002-4214-3953
Karin Hermana NeppelenbroekDepartment of Prosthodontics and Periodontics, Bauru School of Dentistry, University of São Paulo (USP), Bauru, Brazil.ORCID 0000-0001-7086-2667
Priscileila Colerato FerrariDepartment of Pharmaceutical Sciences, State University of Ponta Grossa (UEPG), Ponta Grossa, Brazil.ORCID 0000-0002-4285-6646

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to develop and analyze nystatin:β-cyclodextrin and chlorhexidine:β-cyclodextrin mucoadhesive hydrogels. MATERIALS &

methodsHydrogels were characterized by

resultsThe hydrogel showed high adhesiveness and retention (83.37 ± 2.05%) to the porcine oral mucosa. The drug release from complexed nystatin and chlorhexidine hydrogels was 1.5 (95 µg/cm

conclusionMucoadhesive hydrogels with inclusion complex are promising for oral lesions with greater retention at the treatment site.

Indexed as

Antifungal Agentsbeta-CyclodextrinsChlorhexidineHydrogelsMouth MucosaNystatinAdhesivenessAdministration, BuccalAnimalsCandida albicansDrug LiberationRheologySwineAntifungal Agentsbeta-CyclodextrinsbetadexChlorhexidineHydrogelsNystatinCandida albicanschitosandrug delivery systemdrug permeationinclusion complexmucoadhesionOral mucosa

Identifiers

PMID39976271
PMCPMC11970780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.