Evidence map›Paper›PMID 39976168›Full record

ArticleAllergy2025

Point-of-Care Blood Eosinophils to Predict Preschool Wheeze Attacks.

Kushalinii Hillson, Sara Fontanella, Hernani Almeida, Barbara Pavlou, Katariina Lajunen, Samantha Irving, Ilaria Testa, Yvonne Bingham, Karina Mayoral Oritz, Shane Lacbay and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Kushalinii HillsonNational Heart & Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0002-2675-288X
Sara FontanellaNational Heart & Lung Institute, Imperial College London, London, UK.
Hernani AlmeidaNational Heart & Lung Institute, Imperial College London, London, UK.
Barbara PavlouNational Heart & Lung Institute, Imperial College London, London, UK.
Katariina LajunenNational Heart & Lung Institute, Imperial College London, London, UK.
Samantha IrvingDepartment of Respiratory Paediatrics, Royal Brompton Hospital, London, UK.
Ilaria TestaNational Heart & Lung Institute, Imperial College London, London, UK.
Yvonne BinghamNational Heart & Lung Institute, Imperial College London, London, UK.
Karina Mayoral OritzNational Heart & Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0002-7904-4422
Shane LacbayNational Heart & Lung Institute, Imperial College London, London, UK.
Sophie HayNational Heart & Lung Institute, Imperial College London, London, UK.
Mindy GoreNational Heart & Lung Institute, Imperial College London, London, UK.
Elizabeth ScotneyNational Heart & Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0002-9264-4174
Emmanouil ParaskakisDepartment of Paediatrics, Heraklion University Hospital, University of Crete Medical School, Crete, Greece.
Samatha SonnappaDepartment of Respiratory Paediatrics, Royal Brompton Hospital, London, UK.ORCID https://orcid.org/0000-0002-9189-223X
Louise FlemingNational Heart & Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0002-7268-7433
Andrew BushNational Heart & Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0001-6756-9822
Sejal SaglaniNational Heart & Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0001-5192-6418

Funding

Action Medical ResearchMasonic Charitable FoundationNIHR Imperial Biomedical Research Centre
6 · The paper itself

Abstract

backgroundPost hoc analysis of clinical trials shows blood eosinophil counts (BEC) predict future preschool wheeze attacks; however, prospective usefulness in a clinical setting is unreported. We assessed the feasibility of point-of-care (POC) eosinophil measurements in preschool wheezers and related BEC to symptoms, lung function, and utility in predicting attacks.

methodsChildren aged 1-5 years with recurrent wheeze underwent finger-prick sampling during the outpatient clinic for POC eosinophils, forced oscillation technique (FOT) and/or spirometry, and symptom score (TRACK questionnaire). The utility of BEC and/or the other tests in predicting wheeze attacks in the subsequent 3 months was analysed by comparing those with and without an attack and using a predictive decision tree (DT) model.

resultsSeventy-three children (median age 4.27 years) were recruited; BEC were higher in atopic children (median 0.5 × 10

conclusionPOC blood eosinophils were feasible in a clinical setting. Our preliminary data suggest elevated BEC with a low symptom score predicts a wheeze attack within 3 months.

Indexed as

AsthmaEosinophilsPoint-of-Care SystemsRespiratory SoundsChild, PreschoolFemaleHumansInfantLeukocyte CountMalePrognosisProspective Studiesbiomarkereosinophilsmachine learningpoint‐of‐care testpreschool wheezerisk factorwheeze attacks

Identifiers

PMID39976168
PMCPMC11969302

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.