MicroRNA-Mediated Regulation of Cancer Stem Cells: Implications for Radioresistance and Chemoresistance in Cancer Treatment.

Vasanth Kanth Thasma Loganathbabu, Harin N Ganesh, Ravi Gor, Kandasamy Nagarajan Aruljothi, Satish Ramalingam

Abstract readReview

In one paragraph

Review in MicroRNA (Shariqah, United Arab Emirates), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vasanth Kanth Thasma LoganathbabuDepartment of Genetic Engineering, School of Bio-Engineering, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, 603203, Tamil Nadu, India.

Harin N GaneshDepartment of Genetic Engineering, School of Bio-Engineering, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, 603203, Tamil Nadu, India.

Ravi GorDepartment of Genetic Engineering, School of Bio-Engineering, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, 603203, Tamil Nadu, India.ORCID 0000-0002-3208-8209

Kandasamy Nagarajan AruljothiDepartment of Genetic Engineering, School of Bio-Engineering, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, 603203, Tamil Nadu, India.

Satish RamalingamDepartment of Genetic Engineering, School of Bio-Engineering, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, 603203, Tamil Nadu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are a class of noncoding RNAs that regulate gene expression in cancer cells and Cancer Stem Cells (CSCs), and play an indispensable role in the development of resistance to radiotherapy and chemotherapy in cancer treatment. The dysregulation of miRNAs in CSCs plays a vital role in influencing the features of CSCs and their resistance mechanisms in different types of cancer. These miRNAs are also engaged in regulating important signaling pathways, such as Notch and Wnt, which have an impact on the behavior of CSCs and their response to treatment. The intricate network of miRNAs and their interactions with essential proteins and major pathways highlight their potential as therapeutic targets for controlling cancer stem cell behavior and improving the outcomes of cancer therapy by understanding their effects. Comprehending the complex relationship among the production of microRNA, the environment surrounding the tumor, and the processes by which cells communicate can provide vital knowledge for developing successful treatments to overcome resistance to chemotherapy and radiation in cancer therapy.

Indexed as

Drug Resistance, NeoplasmMicroRNAsNeoplasmsNeoplastic Stem CellsRadiation ToleranceAnimalsGene Expression Regulation, NeoplasticHumansSignal TransductionMicroRNAscancer stem cellscancer therapy.chemoresistancegene expressionMicroRNAradioresistanceself-renewal

Identifiers

PMID39976099

DOI10.1093/nar/gkm995

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.