ReviewCurrent drug research reviews2025
Advances in Human Brain Organoids: Methodological Innovations and Future Directions for Drug Discovery.
Review in Current drug research reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Recapitulating lung cancer metastasisOncology reports · 2026Review
- Autism Spectrum Disorder: The Cerebellum, Genes, and Pathways.Neurology international · 2025Review
- From Better Diagnostics to Earlier Treatment: The Rapidly Evolving Alzheimer's Disease Landscape.Medicina (Kaunas, Lithuania) · 2025Review
- Human brain organoids: an innovative model for neurological disorder research and therapy.Frontiers in cellular neuroscience · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUnderstanding the genetic foundations of brain development has been made possible by the use of traditional biological models. However, these models frequently fail to capture the complexity of human brain development, particularly the considerable cortical expansion that sets humans apart from other vertebrates and non-human primates.
objectivesThe purpose of this review is to outline the methodology, applications, and potential prospects for using human brain organoids as sophisticated models for researching brain development and illness mechanisms.
methodsOrganoids, or three-dimensional (3-D) structures, are generated by utilizing adult or embryonic stem cells to mimic the main structural and functional features of the human brain. The present investigation emphasizes the advantages of these organoids over traditional two-dimensional (2-D) monolayer models in relation to cellular variety and the ability to create complex 3-D networks, addressing various methods established by researchers to culture these cells.
resultsOrganoids precisely mimic numerous features of human brain development, overcoming the limitations of conventional models. They have demonstrated significant utility in investigating the mechanisms that contribute to neurodegenerative diseases like Parkinson's and Alzheimer's, in addition to tumor biology, providing a valuable understanding of both the normal physiological processes and the underlying cause of the human brain.
conclusionHuman brain organoids signify a notable progression in the field of neuroscience research, facilitating enhanced modeling of brain disorders. Future investigations will further enhance these methodologies and examine their applications, leading to innovative therapeutic strategies and broadening the knowledge of human brain disorders.
Indexed as
Identifiers
39976096What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.