Evidence map›Paper›PMID 39976038›Full record

ArticleCurrent neuropharmacology2025

Quantification of [

Michele S Milella, Luciano Minuzzi, Chawki Benkelfat, Jean-Paul Soucy, Alexandre Kirlow, Esther Schirrmacher, Mark Angle, Jeroen A J Verhaeghe, Gassan Massarweh, Andrew J Reader and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current neuropharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Testing PET-[Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Michele S MilellaToxicology Unit, Policlinico Umberto I Hospital-Sapienza, University of Rome, Rome, Italy.
Luciano MinuzziDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Chawki BenkelfatDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada.
Jean-Paul SoucyDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada.
Alexandre KirlowDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada.
Esther SchirrmacherDepartment of Oncology, Division of Oncological Imaging, University of Alberta, Edmonton, AB, Canada.
Mark AngleDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada.
Jeroen A J VerhaegheMolecular Imaging Center Antwerp (MICA), University of Antwerp, Antwerp, Belgium.
Gassan MassarwehDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada.
Andrew J ReaderDepartment of Biomedical Engineering, King's College, London, United Kingdom.
Antonio AliagaDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada.
Jose Eduardo Peixoto-SantosDepartment of Neurology and Neurosurgery, Paulista Medical School, UNIFESP, Sao Paulo, Brazil.
Marie-Christine GuiotDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada.
Eliane KobayashiDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada.
Pedro Rosa-NetoDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada.
Marco LeytonDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada.

Funding

Alzheimer's Association NIRG-08-92090CIHR MOP-115131, MOP-36429Fonds de la recherche en santé du Québec 16326
6 · The paper itself

Abstract

introduction

methodsWe first measured mGluR5 density in postmortem human cerebellum using [

resultsThe postmortem data showed that, relative to the hippocampus, the cerebellum had 35% less mGluR5 immunoreactivity and 94% fewer [

conclusionThe scarce availability of cerebellar allosteric binding sites at autoradiography, compared to immunohistochemistry results, might reflect the presence of distinct mGluR5 isoforms or conformational state. Together with our PET data, these data support the proposition that [

Indexed as

CerebellumOximesPyridinesReceptor, Metabotropic Glutamate 5AdultAgedAutoradiographyCarbon RadioisotopesFemaleHumansMaleMiddle AgedPositron-Emission TomographyPyrrolidinonesRadiopharmaceuticalsYoung Adult1-((3-(methylpyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one3-(6-methylpyridin-2-ylethynyl)cyclohex-2-enone-O-methyloximeCarbon-11Carbon RadioisotopesGRM5 protein, humanOximesPyridinesPyrrolidinonesRadiopharmaceuticalsReceptor, Metabotropic Glutamate 5[11C]ABP688autoradiographykinetic modelingmGluR5positron emission tomographyreceptor imaging.

Identifiers

PMID39976038
PMCPMC12272086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.