Evidence map›Paper›PMID 39976035›Full record

ReviewCurrent gene therapy2026

Gene Therapy and Gene Editing: Current Trends and Future Prospects of Molecular Medicine.

Aniruddha Sen, Vijay Singh, Shailendra Dwivedi, Ruchika Agrawal, Akash Bansal, Shashank Shekhar, Sudhir Shyam Kushwaha

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current gene therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aniruddha SenDepartment of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, 273008, India.ORCID 0009-0007-5446-2015
Vijay SinghDepartment of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, 273008, India.ORCID 0009-0000-7283-6008
Shailendra DwivediDepartment of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, 273008, India.ORCID 0000-0003-2781-1009
Ruchika AgrawalDepartment of ENT, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, 273008, India.
Akash BansalDepartment of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, 273008, India.
Shashank ShekharDepartment of Radiotherapy, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, 273008, India.
Sudhir Shyam KushwahaDepartment of Orthopaedics, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, 273008, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene therapy and genome editing have emerged as transformative approaches in the management of a diverse range of genetic and acquired diseases. This evaluation offers a thorough examination of the present state and prospects of these innovative technologies. Gene therapy is a prospective approach to the treatment and prevention of a variety of conditions, including complex cancers and inherited genetic disorders, which entail the introduction, removal, or modification of genetic material within a patient's cells. Genome editing, particularly through techniques such as CRISPR-Cas9, enables targeted corrections of genetic defects and opens new possibilities for personalized medicine by allowing for precise modifications at the DNA level. The review addresses the ethical implications, clinical applications, and significant advancements of these technologies. This article endeavors to underscore the substantial influence of gene therapy and genome editing on contemporary medicine by assessing the most recent research and clinical trials, thereby emphasizing their potential to revolutionize disease treatment and management.

Indexed as

Gene EditingGenetic Diseases, InbornGenetic TherapyMolecular MedicineCRISPR-Cas SystemsHumansNeoplasmsPrecision Medicineclinical applicationsCRISPR-Cas9disease managementethical considerationsGene therapygenetic disordersgenetic modificationsgenome editingpersonalized medicine

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.