Evidence map›Paper›PMID 39976033›Full record

ArticleCurrent pharmaceutical biotechnology2026

Research on Precision Medicine AI Algorithm for Neuro Immune Gastrointestinal Diseases based on Quantum Biochemistry and Computational Cancer Genetics.

Liangyu Li, Bingyao Li, Guangwen Wang, Siyi Li, Xudong Li, Javier Santos, Ana Maria Gonzalez, Lizhong Guo, Yanyang Tu, Yi Qin

Abstract read
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Article in Current pharmaceutical biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Liangyu LiOffice of the Deputy Director, Tumor Radiotherapy and Treatment Department, Chifeng Cancer Hospital (The Second Affiliated Hospital of Chifeng University), Chifeng City State Cancer Prevention and Treatment Center, Chifeng University, 024000, China.
Bingyao LiOffice of the Deputy Director, Tumor Radiotherapy and Treatment Department, Chifeng Cancer Hospital (The Second Affiliated Hospital of Chifeng University), Chifeng City State Cancer Prevention and Treatment Center, Chifeng University, 024000, China.
Guangwen WangOffice of the Deputy Director, Tumor Radiotherapy and Treatment Department, Chifeng Cancer Hospital (The Second Affiliated Hospital of Chifeng University), Chifeng City State Cancer Prevention and Treatment Center, Chifeng University, 024000, China.
Siyi LiOffice of the Deputy Director, Tumor Radiotherapy and Treatment Department, Chifeng Cancer Hospital (The Second Affiliated Hospital of Chifeng University), Chifeng City State Cancer Prevention and Treatment Center, Chifeng University, 024000, China.
Xudong LiOffice of the Deputy Director, Tumor Radiotherapy and Treatment Department, Chifeng Cancer Hospital (The Second Affiliated Hospital of Chifeng University), Chifeng City State Cancer Prevention and Treatment Center, Chifeng University, 024000, China.
Javier SantosFacultad de Medicina, Universidat Autonoma de Barcelona, 08203 Bellaterra, Spain.
Ana Maria GonzalezLaboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d Hebron Institute de Recerca (VHIR), Vall Hebron Hospital Universitari, Vall d Hebron Barcelona Hospital Campus, Barcelona, Spain.
Lizhong GuoNinth Clinical Medical College, Department of Medicine, Peking University, Peking 100000, China.
Yanyang TuOffice of the Deputy Director, Tumor Radiotherapy and Treatment Department, Chifeng Cancer Hospital (The Second Affiliated Hospital of Chifeng University), Chifeng City State Cancer Prevention and Treatment Center, Chifeng University, 024000, China.
Yi QinOffice of the Deputy Director, Tumor Radiotherapy and Treatment Department, Chifeng Cancer Hospital (The Second Affiliated Hospital of Chifeng University), Chifeng City State Cancer Prevention and Treatment Center, Chifeng University, 024000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study is to conduct network toxicology analysis based on smoking habits and develop a simpler and more effective toxicology product ingestion control system.

backgroundSmoking behavior can affect the pathogenesis and prognosis of neuroimmune gastrointestinal diseases.

aimsThe purpose of developing tools to assist clinical practice is to avoid the harm of cigarettes to the human body.

methodsMolecular dynamics method was used to elucidate the biophysical mechanism of TP53 gene mutation caused by harmful ingredients, and the signaling pathway of midbrain edge excitation was determined by molecular dynamics of nicotine and dopamine receptor D3. The possible involvement of nicotine in neuronal damage was determined through the molecular interaction between nicotine and ACHE. Molecular pathways were analyzed based on the aforementioned biological principles, developed artificial intelligence systems and brain computer interface systems.

resultsSeveral signaling pathways were elucidated, and effective AI algorithms were developed.

conclusionThe accuracy of artificial intelligence systems is over 70%. This study provides clinical doctors with a new precision medicine strategy and tool to regulate patient behavior and reduce disease risk. Other: This project was approved by the Ethics Committee of Chifeng Cancer Hospital and reported to the WHO.

Indexed as

AlgorithmsArtificial IntelligenceGastrointestinal DiseasesPrecision MedicineHumansMolecular Dynamics SimulationSmokingTumor Suppressor Protein p53TP53 protein, humanTumor Suppressor Protein p53artificial intelligencebioinformaticsmolecular dynamicsmolecular mechanismsPrecision medicinequantum physics

Identifiers

PMID39976033

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.