Evidence map›Paper›PMID 39976029›Full record

ReviewCNS & neurological disorders drug targets2025

Serotonergic Dynamics in Autism Spectrum Disorder: Unraveling the Intricate Connection.

Abhishek Chander, Jeetesh Sharma, Shushank Mahajan, Sanchit Dhankhar, Samrat Chauhan, Monika Saini, Sanjana Mehta

Abstract readReview
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In one paragraph

Review in CNS & neurological disorders drug targets, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abhishek ChanderM.M College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana 133-207, Ambala, Haryana, India.
Jeetesh SharmaM.M College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana 133-207, Ambala, Haryana, India.
Shushank MahajanChitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India.
Sanchit DhankharChitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India.
Samrat ChauhanChitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India.
Monika SainiM.M College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana 133-207, Ambala, Haryana, India.
Sanjana MehtaChitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism Spectrum Disorder (ASD) constitutes a group of neurodevelopmental disorders characterized by impairments in verbal and nonverbal communication skills, social interactions, and stereotypes of behavior, with an estimated frequency of 1.2% of children throughout the world. The lack of specific treatments or molecular biomarkers underscores the complexities of ASD as a nonunified clinical entity. Comorbid medical conditions are particularly associated with gastrointestinal issues that may suggest potential interactions between the brain and gut. This review suggests that serotonin plays a significant role in the enteric and central nervous systems in relation to ASD. The modulatory role of serotonin in the enteric nervous system is examined in relation to the pathophysiology of ASD in order to shed light on prospective biomarkers and therapeutic targets that could increase the precision of diagnosis and treatment.

Indexed as

Autism Spectrum DisorderEnteric Nervous SystemSerotoninAnimalsHumansSerotoninautismdisordergenetic.neurologicalSerotoninspectrum

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.