Evidence map›Paper›PMID 39975927›Full record

ArticleResearch square2025

Association of Placental Pathology and antibiotic exposure after birth with the Severity of Necrotizing Enterocolitis in Preterm infants - A Matched Case-Control Study.

Parvesh Mohan Garg, Robin Riddick, Abu Yusuf Ansari, Aubrey Rebentisch, Avinash Shetty, Kristin Adams, William B Hillegass, Padma Garg

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PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Parvesh Mohan GargWake Forest University.ORCID 0000-0001-5949-7304
Robin RiddickUniversity of Mississippi Medical center.
Abu Yusuf AnsariUniversity of Mississippi Medical center.
Aubrey RebentischUniversity of Mississippi Medical Center.
Avinash ShettyUniversity of Mississippi Medial Center.
Kristin AdamsUniversity of Mississippi Medial Center.
William B HillegassUniversity of Mississippi Medial Center.
Padma GargUniversity of Mississippi Medial Center.

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI GOMEZ-SANCHEZ, CELSO ENRIQUE · 2016 to 2025
$38.2M
NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

Objective: To determine the association between antibiotic exposure following birth and necrotizing enterocolitis (NEC) severity in preterm infants. Methods: This single center matched case-control study included infants with NEC (n=107) and matched controls (n= 130) with antibiotic exposure =< 3 days and > 3 days after birth. Results: Out of 212 infants,103 infants (48.5%) received antibiotics =< 3 days, and 109 infants (51.5%) received antibiotics >3 days. On the multivariate regression, Infants receiving antibiotics for >3 day had higher risk for medical NEC (aOR 2.61,95% CI 1.35 -5.16; p=0.005) and surgical NEC (aOR 3.33, CI 1.57-7.40; p=0.02) than controls. In NEC cohort, those receiving antibiotics for >3 days were like to die (OR 7.88,95% CI 1.99- 53.74; p=0.010) than those receiving antibiotics <3 days. Conclusion: Infants exposed with early antibiotics >3 days after birth were more likely associated with NEC and were at greater risk of death.

Identifiers

PMID39975927
PMCPMC11838731

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.