Evidence map›Paper›PMID 39975922›Full record

ArticleResearch square2025

RNAs anchoring replication complex control initiation and firing of DNA replication.

Simone Ummarino, Larysa Poluben, Alex K Ebralidze, Ida Autiero, Yanzhou Zhang, Theodore Paniza, Madhura Deshpande, Lucrezia Rinaldi, Johnathan D Lee, Mahmoud A Bassal and 7 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Simone UmmarinoHarvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA, 02115, USA.
Larysa PolubenHarvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA, 02115, USA.
Alex K EbralidzeHarvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA, 02115, USA.
Ida AutieroInstitute of Biostructures and Bioimaging, CNR, Naples, 80100, Italy.ORCID 0000-0001-8886-8063
Yanzhou ZhangHarvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA, 02115, USA.
Theodore PanizaCenter for Reproductive Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Madhura DeshpandeCenter for Reproductive Medicine, Weill Cornell Medical College, New York, NY 10065, USA.ORCID 0000-0002-9942-4932
Lucrezia RinaldiHarvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA, 02115, USA.
Johnathan D LeeHarvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA, 02115, USA.ORCID 0000-0002-1229-0098
Mahmoud A BassalHarvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA, 02115, USA.
Bon Q TrinhUniversity of Virginia.
Steven P BalkHarvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA, 02115, USA.ORCID 0000-0002-4546-7371
Robert FlaumenhaftBeth Israel Deaconess Medical Center, Division of Hemostasis and Thrombosis, Harvard Medical School, Boston, MA, 02115, USA.
Jeannine GerhardtCenter for Reproductive Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Sergei M MirkinDepartment of Biology, Tufts University, Medford, MA 02155, USA.ORCID 0000-0003-4576-7582
Daniel G TenenHarvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA, 02115, USA.ORCID 0000-0002-6423-3888
Annalisa Di RuscioHarvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA, 02115, USA.ORCID 0000-0002-9705-4245

Funding

Transcriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Jason Daniel Buenrostro · 2017 to 2026
$24.6M
PROGRAM IN BLOOD COAGULATION AND VASCULAR BIOLOGYT32HL007917 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Robert C Flaumenhaft · 1999 to 2026
$11.1M
Mechanisms of regulation by RNA in acute myeloid leukemiaR35CA197697 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TENEN, DANIEL G · 2015 to 2021
$7.1M
NIGMS Equipment SupplementR35GM130322 · NIGMS · TUFTS UNIVERSITY MEDFORD · PI SERGEI MIRKIN · 2019 to 2026
$4.6M
Understanding the role of cell-cycle specific RNAs in hematopoiesisR01DK136116 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Annalisa Di Ruscio · 2022 to 2026
$1.7M
Regulatory role of long noncoding RNAs in normal and cancer cellsR50CA211304 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI EBRALIDZE, ALEXANDER K · 2017 to 2021
$1.3M
Noncoding RNA-DNMT1 interactions in hematopoiesisR01DK103858 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TENEN, DANIEL G · 2015 to 2017
$783k
Determining the role of DNMT-interacting RNAs in myeloid disordersR00CA188595 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI DI RUSCIO, ANNALISA · 2017 to 2019
$747k
Enhancer RNA-mediated Tumor Suppressor Gene Expression in Normal and Malignant HematopoiesisK01CA222707 · NCI · UNIVERSITY OF VIRGINIA · PI TRINH, BON Q · 2017 to 2021
$571k
The role of long noncoding RNAs in acute myeloid leukemiaR21CA270067 · NCI · UNIVERSITY OF VIRGINIA · PI TRINH, BON Q · 2024 to 2024
$415k
NCI NIH HHS K01 CA222707NCI NIH HHS R00 CA188595NCI NIH HHS R21 CA270067NCI NIH HHS R35 CA197697NCI NIH HHS R50 CA211304NHLBI NIH HHS P01 HL131477NHLBI NIH HHS T32 HL007917NIDDK NIH HHS R01 DK103858NIDDK NIH HHS R01 DK136116NIGMS NIH HHS R35 GM130322
6 · The paper itself

Abstract

Coordinated initiation of DNA replication is essential to ensure efficient and timely DNA synthesis. Yet, molecular mechanism describing how replication initiation is coordinated in eukaryotic cells is not completely understood. Herein, we present data demonstrating a novel feature of RNAs transcribed in the proximity of actively replicating gene loci. We show that RN

Identifiers

PMID39975922
PMCPMC11838740

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.