Evidence map›Paper›PMID 39975893›Full record

ArticleResearch square2025

Metabolic flux analysis in hiPSC-CMs reveals insights into cardiac dysfunction in propionic acidemia Eva Richard.

Eva Richard, Hannah Marchuk, Mar Álvarez, Wentao He, Xiaoxin Chen, Lourdes R Desviat, Guo-Fang Zhang

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Eva RichardUniversidad Autónoma de Madrid: Universidad Autonoma de Madrid.
Hannah MarchukDuke University.
Mar ÁlvarezUniversidad Autónoma de Madrid: Universidad Autonoma de Madrid.
Wentao HeDuke University.
Xiaoxin ChenCoriell Institute for Medical Research.
Lourdes R DesviatUniversidad Autónoma de Madrid: Universidad Autonoma de Madrid.
Guo-Fang ZhangDuke University.ORCID 0000-0003-3484-5864

Funding

NRF2-ACSS2 Axis in Alcohol-induced Metabolic Reprogramming and Esophageal PathologyR01AA030026 · NIAAA · CORIELL INSTITUTE FOR MEDICAL RESEARCH · PI XIAOXIN Luke CHEN, Guofang Zhang · 2022 to 2026
$2.9M
Triacetin Treatment for Propionic Acidemia by Rebalancing the Acetyl-CoA/Propionyl-CoA MetabolismR21TR005163 · NCATS · DUKE UNIVERSITY · PI CHEN, XIAOXIN LUKE, ZHANG, GUOFANG · 2024 to 2025
$431k
NCATS NIH HHS R21 TR005163NIAAA NIH HHS R01 AA030026
6 · The paper itself

Abstract

Propionic acidemia is an inborn error of metabolism caused by mutations in either the

Indexed as

cardiac diseasesfatty acid metabolismglucose metabolismhuman induced pluripotent stem cell-derived cardiomyocytesmetabolic fluxpropionic acidemia

Identifiers

PMID39975893
PMCPMC11838748

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.