Elevated Micro- and Nanoplastics Detected in Preterm Human Placentae.
Michael Jochum, Marcus Garcia, Alexandra Hammerquist, Jacquelyne Howell, Myla Stanford, Rui Liu, Marian Olewine, Eliane El Hayek, Emily Phan, Lori Showalter and 5 more
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
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2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Kjersti AagaardOregon National Primate Research Center & HCA Healthcare and HCA Healthcare Research Institute & Boston Children's Hospital, Harvard Medical School.
University of New Mexico Center for Metals in Biology and Medicine - equipment supplementP20GM130422 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Sebastian Medina · 2020 to 2026
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Mechanisms of Vascular Toxicity from Inhaled ToxicantsR01ES014639 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J · 2008 to 2023
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Source of the Placental MicrobiomeR01HD091731 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI AAGAARD, KJERSTI MARIE · 2017 to 2021
Recent analytical advancements have uncovered increasing micro- and nanoplastics (MNPs) in environmental, dietary, and biological domains, raising concerns about their health impacts. Preterm birth (PTB), a leading cause of maternal and neonatal morbidity and mortality, may be influenced by MNP exposure, yet this relationship remains unexplored. This study quantified 12 MNP polymers in placentae from term (n=87) and preterm (n=71) deliveries using pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS). Cumulative MNP concentrations were 28% higher in PTB placentae (mean ±SD: 224.7 ± 180.7 μg/g vs. 175.5 ± 137.9 μg/g; p=0.038). Polyvinyl chloride (PVC), polyethylene terephthalate (PET), polyurethane (PU), and polycarbonate (PC) were significantly elevated in PTB, and PET, PU, and PC inversely correlated with gestational age and birth weight. Logistic regression identified PVC and PC as independent predictors of PTB. These findings suggest total and specific MNPs are associated with PTB, providing actionable insights and emphasizing the importance of minimizing exposure during pregnancy.
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Elevated Micro- and Nanoplastics Detected in Preterm Human Placentae. · full record | OpenQuestion