ArticleHeliyon2025
New optical coherence tomography biomarker for diagnosis of acute optic neuritis in multiple sclerosis.
Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Association of Peripapillary Retinal Nerve Fibre Layer Thickness with Disability and MRI Findings in Multiple Sclerosis: A Retrospective Single-Centre Cohort Study.Medicina (Kaunas, Lithuania) · 2026Article
- Article
- Imaging biomarkers in optic neuritis: current tools and future directions.Frontiers in neurology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Is imaging of retrolaminar optic nerve, during attack of acute optic neuritis in multiple sclerosis valuable? Methods: This is a prospective observational Case series study. Twenty two patients recruited from Al-Azhar University Hospitals and Charity Eye Centre (El-Mustafa Eye Centre, Cairo); from October 2022 to February 2024. The patients were referred; as, they had developed episode of acute optic neuritis. Full ophthalmic and neurological examinations were done for all patients within 2 weeks of acute optic neuritis. Imaging of peripapillary retinal nerve fiber layer by conventional spectral domain optical coherence tomography (OCT), and retrolaminar part of optic nerve by enhanced depth imaging OCT were done for both acute optic neuritis eyes and the fellow eyes. Results: A total of 44 eyes of 22 MS patients (18 females, 4 males) with the mean age of 30.54 ± 9.65 years were included in this study. The best corrected visual acuity (BCVA) was significantly less in the optic neuritis eyes (median = 0.30) than in the fellow eyes (median = 0.70), Conclusion: Using enhanced depth imaging OCT during acute attack of optic neuritis revealed retrolaminar hyper reflective foci as a new biomarker.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.