Evidence map›Paper›PMID 39975665›Full record

ArticleRoyal Society open science2025

Dynamic kinetic resolution-mediated synthesis of C-3 hydroxylated arginine derivatives.

Ye Zheng, Zhenyu Chen, Guy J Clarkson, Stephen A Marshall, Jianliang Xiao, Christopher J Schofield, Martin Wills, Andrew V Stachulski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Royal Society open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ye ZhengDepartment of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
Zhenyu ChenDepartment of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, UK.
Guy J ClarksonDepartment of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
Stephen A MarshallDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
Jianliang XiaoDepartment of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, UK.
Christopher J SchofieldDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.ORCID https://orcid.org/0000-0002-0290-6565
Martin WillsDepartment of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
Andrew V StachulskiDepartment of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, UK.ORCID https://orcid.org/0000-0002-5100-8884

Funding

Wellcome Trust
6 · The paper itself

Abstract

Hydroxylated amino acids and their derivatives, including those found in proteins, are important in biology and medicinal chemistry. Incubation of N-acetyl-l-arginine with clavaminic acid synthase, a key oxygenase in clavulanic acid biosynthesis, affords a (3R)-hydroxylated product that is identical to material obtained by total synthesis from Boc-beta alanine. The key step employed dynamic kinetic resolution (DKR) of a β-ketoester precursor, achieved in high diastereomeric and enantiomeric excess using an (R)-SEGPHOS/Ru(II) catalyst. The results highlight the utility of DKR for the preparation of C-3 hydroxylated amino acid derivatives.

Indexed as

antibioticsasymmetric synthesisbiotransformationcatalysishydroxy amino-acids

Identifiers

PMID39975665
PMCPMC11836541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.