ArticleJournal of parasitic diseases : official organ of the Indian Society for Parasitology2025
Investigating therapeutic efficacy of silymarin on intestinal and muscular phases of trichinellosis: an experimental study.
Article in Journal of parasitic diseases : official organ of the Indian Society for Parasitology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Chemical investigation and anti-trichinellosis activity of some ficus species leaves: in silico supported in vitro study.BMC complementary medicine and therapies · 2026Article
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9 authors.
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Abstract
Trichinellosis, one of the parasitic zoonoses, is treated with a benzimidazole derivative, primarily albendazole. However, this treatment has a lot of side effects and is not sufficiently effective in killing the encysted larvae. Silymarin, a polyphenolic flavonoid, has been proven to have anti-parasitic activities and various medical uses. The current study aimed to evaluate silymarin efficacy against intestinal and muscular phases of murine trichinellosis compared to the standard drug; albendazole. Forty-eight mice were divided into four discrete groups: healthy model; diseased model; silymarin treatment; and albendazole treatment. The assessment of therapy efficacy was conducted parasitologically through counting the adult worms and muscle larvae, histopathologically through examination of the intestinal and muscular tissues, and, immunohistochemically through muscular expression of the vascular endothelial growth factor. Both silymarin and albendazole-treated groups demonstrated a statistically significant decrease (
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