Evidence map›Paper›PMID 39975551›Full record

ArticleFrontiers in immunology2025

Ruxolitinib synergizes with regulatory T cells to improve inflammation but has no added benefits in decreasing albuminuria in SLE.

Mi-Ae Lyu, Ximing Tang, Maria Gabriela Raso, Meixian Huang, Ke Zeng, Tara Sadeghi, Christopher R Flowers, Simrit Parmar

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mi-Ae LyuDepartment of Lymphoma/Myeloma, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States.
Ximing TangDepartment of Translational Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States.
Maria Gabriela RasoDepartment of Translational Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States.
Meixian HuangDepartment of Lymphoma/Myeloma, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States.
Ke ZengDepartment of Lymphoma/Myeloma, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States.
Tara SadeghiCellenkos Inc., Houston, TX, United States.
Christopher R FlowersDepartment of Lymphoma/Myeloma, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States.
Simrit ParmarDepartment of Microbial Pathogenesis & Immunology, Texas A&M University, Bryan, TX, United States.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

Background: Umbilical cord blood (UCB)-derived CD4 Methods: Results: In a dose-dependent manner, ruxolitinib addition synergizes with UCB-Tregs to suppress SLE-PBMC proliferation, inhibit CD8 Conclusions: Our results demonstrate that the addition of ruxolitinib to UCB-Tregs increases UCB-Tregs suppressor function and their persistence

Indexed as

AlbuminuriaLupus Erythematosus, SystemicPyrazolesT-Lymphocytes, RegulatoryAnimalsCytokinesDisease Models, AnimalFemaleFetal BloodHumansInflammationMiceNitrilesPyrimidinesCytokinesNitrilesPyrazolesPyrimidinesruxolitinibadoptive cell therapyallogeneicinflammationJAK/STAT pathwayregulatory T cells (Tregs)ruxolitinibsystemic lupus erythematosus (SLE)umbilical cord blood (UCB)

Identifiers

PMID39975551
PMCPMC11836023

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.