Evidence map›Paper›PMID 39975413›Full record

ArticlebioRxiv : the preprint server for biology2025

Cellular mechanisms underlying beneficial versus detrimental effects of bacterial antitumor immunotherapy.

Jesse Garcia Castillo, Sebastian Fernandez, Timothy Campbell, Diego Gonzalez-Ventura, Jacob Williams, Julia Ybarra, Nicole Flores Hernandez, Elina Wells, Daniel A Portnoy, Michel DuPage

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Jesse Garcia Castillo
Sebastian Fernandez
Timothy Campbell
Diego Gonzalez-Ventura
Jacob Williams
Julia Ybarra
Nicole Flores Hernandez
Elina Wells
Daniel A Portnoy
Michel DuPage

Funding

The role of Listeria cyclic-di-AMP during infection and immunityP01AI063302 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI PORTNOY, DANIEL A · 2004 to 2025
$45.5M
Reversing cancer immunosuppression using attenuated Listeria monocytogenesR01CA283604 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Michel DuPage, DANIEL A PORTNOY · 2024 to 2026
$1.4M
The UC Berkeley MARC: Shaping the Next Generation of Scientific LeadersT34GM145535 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Ellen A Lumpkin · 2022 to 2026
$839k
NCI NIH HHS R01 CA283604NIAID NIH HHS P01 AI063302NIGMS NIH HHS T34 GM145535
6 · The paper itself

Abstract

Bacteria engineered to express tumor antigens as a cancer vaccine have yielded mixed results. Here, we utilized an attenuated strain of

Identifiers

PMID39975413
PMCPMC11838217

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.