Evidence map›Paper›PMID 39975384›Full record

ArticlebioRxiv : the preprint server for biology2025

Ku suppresses RNA-mediated innate immune responses in human cells to accommodate primate-specific Alu expansion.

Yimeng Zhu, Angelina Li, Suvrajit Maji, Brian J Lee, Sophie M Korn, Jake A Gertie, Tyler J Dorrity, Jianhua Wang, Kyle J Wang, Amandine Pelletier and 12 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Yimeng Zhu
Angelina Li
Suvrajit Maji
Brian J Lee
Sophie M Korn
Jake A Gertie
Tyler J Dorrity
Jianhua Wang
Kyle J Wang
Amandine Pelletier
Daniel F Moakley
Rachel D Kelly
Antony B Holmes
Raul Rabadan
David R Edgell
Caroline Schild Poulter
Mauro Modesti
Anna-Lena Steckelberg
Eric A Hendrickson
Hachung Chung
Chaolin Zhang
Shan Zha

Funding

Medical Scientist Training ProgramT32GM145440 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STEVEN L REINER · 2022 to 2026
$7.3M
Complexity and evolution of splicing-regulatory networksR35GM145279 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Chaolin Zhang · 2022 to 2026
$4.6M
Investigation of Self-Nucleic Acids as a Trigger for NeuroinflammationR01NS127802 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Hachung Chung · 2022 to 2026
$2.0M
Understanding the antiviral roles of acellular RNA quality control pathwayR35GM150778 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Anna-Lena Steckelberg · 2023 to 2026
$1.6M
NIGMS NIH HHS R35 GM145279NIGMS NIH HHS R35 GM150778NIGMS NIH HHS T32 GM145440NINDS NIH HHS R01 NS127802
6 · The paper itself

Abstract

Ku70 and Ku80 form Ku, a ring-shaped protein that initiates the non-homologous end-joining (NHEJ) DNA repair pathway.

Identifiers

PMID39975384
PMCPMC11838425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.