Evidence map›Paper›PMID 39975381›Full record

ArticlebioRxiv : the preprint server for biology2025

Cholesterol-mediated Lysosomal Dysfunction in

Louise A Mesentier-Louro, Camille Goldman, Alain Ndayisaba, Alice Buonfiglioli, Rikki B Rooklin, Braxton R Schuldt, Abigail Uchitelev, Vikram Khurana, Joel W Blanchard

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Louise A Mesentier-LouroIcahn School of Medicine, Mount Sinai, New York, NY, USA.ORCID 0000-0002-0937-9331
Camille GoldmanIcahn School of Medicine, Mount Sinai, New York, NY, USA.ORCID 0000-0002-9089-7290
Alain NdayisabaAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.ORCID 0000-0001-7611-7115
Alice BuonfiglioliIcahn School of Medicine, Mount Sinai, New York, NY, USA.ORCID 0000-0002-5550-9360
Rikki B RooklinIcahn School of Medicine, Mount Sinai, New York, NY, USA.ORCID 0009-0009-8509-7529
Braxton R SchuldtIcahn School of Medicine, Mount Sinai, New York, NY, USA.ORCID 0000-0002-1737-707X
Abigail UchitelevIcahn School of Medicine, Mount Sinai, New York, NY, USA.ORCID 0009-0009-8604-0014
Vikram KhuranaAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.ORCID 0000-0002-4018-5527
Joel W BlanchardIcahn School of Medicine, Mount Sinai, New York, NY, USA.ORCID 0000-0003-3142-2970

Funding

Construction of an Integrated Immune-Vascular Brain - Chip as a Platform for the Study, Drug Screening, and Treatments of Alzheimer's DiseaseUH3NS115064 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BLANCHARD, JOEL WILLIAM, KELLIS, MANOLIS · 2021 to 2023
$3.5M
Understanding Cell-type Vulnerability and Oxidative Stress Pathology in Parkinson's Disease Using Isogenic Human Dopaminergic NeuronsR01NS114239 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BLANCHARD, JOEL WILLIAM · 2020 to 2024
$2.2M
NINDS NIH HHS R01 NS114239NINDS NIH HHS UH3 NS115064
6 · The paper itself

Abstract

The pathological hallmark of neurodegenerative disease is the aberrant post-translational modification and aggregation of proteins leading to the formation of insoluble protein inclusions. Genetic factors like

Indexed as

Alzheimer’s DiseaseAPOE4AstrocytesCholesterol metabolismiPSC-derived brain modelLewy Body DementiaLysosomal dysfunctionmiBrainNeurodegenerationα-Synuclein

Identifiers

PMID39975381
PMCPMC11839026

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.