In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
12 authors.
Nicole R WestWaisman Center, University of Wisconsin-Madison, 1500 Highland Ave., Madison, WI 53705.ORCID 0000-0003-0446-4294 Kalpana Hanthanan ArachchilageWaisman Center, University of Wisconsin-Madison, 1500 Highland Ave., Madison, WI 53705.ORCID 0000-0002-0849-9534 Shawn MacGregorWaisman Center, University of Wisconsin-Madison, 1500 Highland Ave., Madison, WI 53705.
Masoumeh HosseiniWaisman Center, University of Wisconsin-Madison, 1500 Highland Ave., Madison, WI 53705.
Ryan D RisgaardWaisman Center, University of Wisconsin-Madison, 1500 Highland Ave., Madison, WI 53705.
Pubudu KumarageWaisman Center, University of Wisconsin-Madison, 1500 Highland Ave., Madison, WI 53705.ORCID 0009-0003-9081-9115 Jose L MartinezWaisman Center, University of Wisconsin-Madison, 1500 Highland Ave., Madison, WI 53705.
Su-Chun ZhangWaisman Center, University of Wisconsin-Madison, 1500 Highland Ave., Madison, WI 53705.
Andre M M SousaWaisman Center, University of Wisconsin-Madison, 1500 Highland Ave., Madison, WI 53705.ORCID 0000-0003-1740-5066 Anita BhattacharyyaWaisman Center, University of Wisconsin-Madison, 1500 Highland Ave., Madison, WI 53705.ORCID 0000-0002-0360-7145 Funding
WISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MAILICK, MARSHA RUTH · 1985 to 2015
$25.2MSupplement to TR01 Human cortical development and neural plasticity altered by trisomy 21R01HD106197 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI BHATTACHARYYA, ANITA, ZHANG, SU-CHUN · 2021 to 2025
$11.4MWaisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Qiang Chang · 2021 to 2026
$8.5MIntegrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5MData Science for Diverse Scholars in Down Syndrome Research (DS3)R25HD114950 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Joaquin M. Espinosa · 2024 to 2026
$1.2MModeling Basal Forebrain Cholinergic Neurons in Down syndromeR36AG072108 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI MARTINEZ, JOSE LUIS · 2021 to 2022
$144kMechanisms underlying the development, evolution, and function of human-specific cortical dopaminergic interneuronsF30MH140382 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Ryan David Risgaard · 2025 to 2026
$78kInvestigating the susceptibility of basal forebrain cholinergic neurons in individuals with Down syndromeF99AG086925 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI WEST, NICOLE · 2024 to 2025
$74kNIA NIH HHS F99 AG086925NIA NIH HHS R36 AG072108NICHD NIH HHS P30 HD003352NICHD NIH HHS P50 HD105353NICHD NIH HHS R01 HD106197NICHD NIH HHS R25 HD114950NIGMS NIH HHS T32 GM140935NIMH NIH HHS F30 MH140382
6 · The paper itselfAbstract
introductionBasal forebrain cholinergic neurons (BFCNs) are integral to learning, attention, and memory, and are prone to degeneration in Down syndrome (DS), Alzheimer's disease, and other neurodegenerative diseases. However, the mechanisms that lead to the degeneration of these neurons are not known.
methodsSingle-nucleus gene expression and ATAC sequencing were performed on postmortem human basal forebrain from unaffected control and DS tissue samples at 0-2 years of age (n=4 each).
resultsSequencing analysis of postmortem human basal forebrain identifies gene expression differences in DS early in life. Genes encoding proteins associated with energy metabolism pathways, specifically oxidative phosphorylation and glycolysis, and genes encoding antioxidant enzymes are upregulated in DS BFCNs. DISCUSSION: Multiomic analyses reveal that energy metabolism may be disrupted in DS BFCNs by birth. Increased oxidative phosphorylation and the accumulation of reactive oxygen species byproducts may be early contributors to DS BFCN neurodegeneration.
Indexed as
Basal Forebrain Cholinergic Neurons (BFCNs)Down syndromeGlycolysisOxidative Phosphorylation (OXPHOS)Reactive Oxygen Species (ROS)snMultiomic Analysis
Identifiers
PMID39975363
PMCPMC11839037
What OpenQuestion holds
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