Evidence map›Paper›PMID 39975357›Full record

ArticlebioRxiv : the preprint server for biology2025

LRRC8A-containing anion channels promote glioblastoma proliferation via a WNK1/mTORC2-dependent mechanism.

Antonio M Fidaleo, Martin D Bach, Shaina Orbeta, Iskandar F Abdullaev, Nina Martino, Alejandro P Adam, Mateo A Boulos, Nickolai O Dulin, Alexandra R Paul, Yu-Hung Kuo and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Antonio M FidaleoDepartment of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, NY, USA.
Martin D BachDepartment of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, NY, USA.
Shaina OrbetaDepartment of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, NY, USA.
Iskandar F AbdullaevDepartment of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, NY, USA.ORCID 0009-0004-5175-0722
Nina MartinoDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
Alejandro P AdamDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.ORCID 0000-0001-6285-7235
Mateo A BoulosDepartment of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, NY, USA.ORCID 0009-0005-4328-3025
Nickolai O DulinDepartment of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL, USA.ORCID 0000-0001-6096-5822
Alexandra R PaulDepartment of Neurosurgery, Albany Medical College, Albany, NY, USA.
Yu-Hung KuoNeurosurgery, Luminis Health Anne Arundel Medical Center, Annapolis, MD, USA.
Alexander A MonginDepartment of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, NY, USA.ORCID 0000-0002-2501-3778

Funding

Fibroblast Biology and Pulmonary FibrosisR01HL149993 · NHLBI · UNIVERSITY OF CHICAGO · PI DULIN, NICKOLAI O · 2020 to 2023
$2.1M
Oxidative Stress and Pathological Glutamate Release in StrokeR01NS111943 · NINDS · ALBANY MEDICAL COLLEGE · PI MONGIN, ALEXANDER A · 2019 to 2023
$2.0M
NHLBI NIH HHS R01 HL149993NINDS NIH HHS R01 NS111943
6 · The paper itself

Abstract

Leucine-rich repeat-containing protein 8A (LRRC8A) is the essential subunit of ubiquitous volume-regulated anion channels (VRACs). LRCC8A is overexpressed in several cancers and promotes negative survival outcomes via a poorly defined mechanism. Here, we explored the role of LRRC8A and VRACs in the progression of glioblastoma (GBM), the most common and deadly primary brain tumor. We found that, as compared to healthy controls,

Indexed as

CancerCell biologyMolecular biology

Identifiers

PMID39975357
PMCPMC11838495

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.