Evidence map›Paper›PMID 39975348›Full record

ArticlebioRxiv : the preprint server for biology2025

Comparative Genomics Reveals LINE-1 Recombination with Diverse RNAs.

Cheuk-Ting Law, Kathleen H Burns

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Cheuk-Ting LawDepartment of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.ORCID 0009-0006-3381-2664
Kathleen H BurnsDepartment of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.ORCID 0000-0003-1620-3761

Funding

Consequences of retrotransposition on genome integrityR01CA276112 · NCI · DANA-FARBER CANCER INST · PI KATHLEEN H BURNS, Alice Eunjung Lee · 2023 to 2026
$2.9M
Characterizing the LINE-1 Retrotransposition-Replication ConflictR01CA240816 · NCI · DANA-FARBER CANCER INST · PI BURNS, KATHLEEN H · 2020 to 2024
$2.0M
Immunological consequences of LINE-1 expression in cancerR01CA289390 · NCI · GEORGE WASHINGTON UNIVERSITY · PI KATHLEEN H BURNS, Katherine B Chiappinelli · 2024 to 2026
$1.9M
Single Molecule Detection of L1 Insertions and IntermediatesUG3NS132127 · NINDS · DANA-FARBER CANCER INST · PI BERNSTEIN, BRADLEY EVAN, BURNS, KATHLEEN H · 2023 to 2024
$879k
NCI NIH HHS R01 CA240816NCI NIH HHS R01 CA276112NCI NIH HHS R01 CA289390NINDS NIH HHS UG3 NS132127
6 · The paper itself

Abstract

Long interspersed element-1 (LINE-1, L1) retrotransposons are the most abundant protein-coding transposable elements (TE) in mammalian genomes, and have shaped genome content over 170 million years of evolution. LINE-1 is self-propagating and mobilizes other sequences, including

Indexed as

chimeric insertionscomparative genomicsLINE-1multiple sequence alignmenttransposable elementstrans-splicingU6 snRNA

Identifiers

PMID39975348
PMCPMC11838501

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.