Evidence map›Paper›PMID 39975341›Full record

ArticlebioRxiv : the preprint server for biology2025

Cis-regulatory chromatin contacts form de novo in the absence of loop extrusion.

Nicholas G Aboreden, Han Zhao, Fengnian Shan, Fuhai Liu, Haoyue Zhang, Gerd A Blobel

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Nicholas G AboredenPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Han ZhaoInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.
Fengnian ShanInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.
Fuhai LiuInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.
Haoyue ZhangInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.
Gerd A BlobelPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008216 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, DOUGLAS J · 1987 to 2023
$8.3M
Engineering and Imaging 3D genome structure-function dynamics across time scalesU01DK127405 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BLOBEL, GERD A, PHILLIPS-CREMINS, JENNIFER ELIZABETH · 2020 to 2024
$5.7M
Roles of CBP &PCAF During Hematopoietic DifferentiationR01DK058044 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI BLOBEL, GERD A · 2002 to 2023
$4.5M
Investigating the role of Ldb1 in chromatin architecture and transcription during erythroid cell state transitionsF31DK136200 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI ABOREDEN, NICHOLAS · 2024 to 2024
$49k
NIDDK NIH HHS F31 DK136200NIDDK NIH HHS R01 DK058044NIDDK NIH HHS U01 DK127405NIGMS NIH HHS T32 GM008216
6 · The paper itself

Abstract

NIPBL promotes chromatin loop extrusion by the cohesin complex until it stalls at convergently oriented CTCF sites, leading to the formation of structural loops. However, to what extent loop extrusion contributes to the establishment vs maintenance of

Identifiers

PMID39975341
PMCPMC11838467

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.