Evidence map›Paper›PMID 39975335›Full record

ArticlebioRxiv : the preprint server for biology2025

A molecular switch at the yeast mitoribosomal tunnel exit controls cytochrome

Andreas Carlström, Joseph B Bridgers, Mary Couvillion, Abeer Singh, Ignasi Forné, Axel Imhof, L Stirling Churchman, Martin Ott

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Andreas CarlströmDepartment of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden.
Joseph B BridgersDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Mary CouvillionDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Abeer SinghDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, 405 30 Gothenburg, Sweden.
Ignasi FornéBiomedical Center Munich, Faculty of Medicine, Ludwig Maximilian University of Munich, 82152, Planegg-Martinsried, Germany.
Axel ImhofBiomedical Center Munich, Faculty of Medicine, Ludwig Maximilian University of Munich, 82152, Planegg-Martinsried, Germany.ORCID 0000-0003-2993-8249
L Stirling ChurchmanDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Martin OttDepartment of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden.ORCID 0000-0001-6367-3091

Funding

Nuclear-mitochondrial co-regulation during mitochondrial biogenesisR01GM123002 · NIGMS · HARVARD MEDICAL SCHOOL · PI CHURCHMAN, LEE STIRLING · 2017 to 2020
$1.3M
NIGMS NIH HHS R01 GM123002
6 · The paper itself

Abstract

Mitochondrial gene expression needs to be balanced with cytosolic translation to produce oxidative phosphorylation complexes. In yeast, translational feedback loops involving lowly expressed proteins called translational activators help to achieve this balance. Synthesis of cytochrome

Indexed as

feedback loopMitochondriamitochondrial ribosomeprotein biogenesistranslation

Identifiers

PMID39975335
PMCPMC11838262

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.